| Effect of trans-retinoic acid in the inhibition of cholesteatoma in guinea pigs. | |
| | |
MedLine Citation:
|
PMID: 18392502 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Middle ear cholesteatoma affected more than 5 million people until the 80;s. Many animal models were used, unsuccessfully, to study an alternative therapy to cholesteatoma. AIM: observe the effect of the trans-retinoic acid in the inhibition of middle ear cholesteatomas induced by propylene glycol. STUDY DESIGN: Clinical and Experimental. METHODS: 25 guinea pigs were submitted to the application of a 100% propylene glycol solution in their bulla bilaterally and a solution of trans-retinoic acid was applied locally in the external right ear, while in the left ear saline solution was applied (control ear). The guinea pigs were slaughtered and their temporal bones were prepared for macroscopic and histological analysis. RESULTS: The macroscopic findings had evidenced the presence of cholesteatoma in 25% of the right ears and 85% of the left ears (P=0.0003 *). The histological study had evidenced the presence of cholesteatoma in 30% of right ears and 75% of the left ears (P=0.0104*). CONCLUSION: The local use of the trans-retinoic acid is effective in inhibiting the induced formation of cholesteatomas in guinea pigs. |
| | |
Authors:
|
Marcos Luiz Antunes; Yotaka Fukuda; Norma de Oliveira Penido; Rimarcs Ferreira |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Brazilian journal of otorhinolaryngology Volume: 74 ISSN: 1808-8694 ISO Abbreviation: - Publication Date: 2008 Jan-Feb |
Date Detail:
|
Created Date: 2008-04-08 Completed Date: 2008-08-07 Revised Date: 2008-10-06 |
Medline Journal Info:
|
Nlm Unique ID: 101207337 Medline TA: Braz J Otorhinolaryngol Country: Brazil |
Other Details:
|
Languages: eng Pagination: 53-60 Citation Subset: IM |
Affiliation:
|
Faculdade de medicina do ABC, SP, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Animals Antineoplastic Agents / therapeutic use* Cholesteatoma, Middle Ear / chemically induced, pathology, prevention & control* Disease Models, Animal Female Guinea Pigs Male Propylene Glycol* Prospective Studies Tretinoin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 302-79-4/Tretinoin; 57-55-6/Propylene Glycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitative analysis of myelinic fibers in human laryngeal nerves according to age.
Next Document: Evaluation of a new mouthwash on caseous formation.