Document Detail

Effect of trans-retinoic acid in the inhibition of cholesteatoma in guinea pigs.
MedLine Citation:
PMID:  18392502     Owner:  NLM     Status:  MEDLINE    
Middle ear cholesteatoma affected more than 5 million people until the 80;s. Many animal models were used, unsuccessfully, to study an alternative therapy to cholesteatoma. AIM: observe the effect of the trans-retinoic acid in the inhibition of middle ear cholesteatomas induced by propylene glycol. STUDY DESIGN: Clinical and Experimental. METHODS: 25 guinea pigs were submitted to the application of a 100% propylene glycol solution in their bulla bilaterally and a solution of trans-retinoic acid was applied locally in the external right ear, while in the left ear saline solution was applied (control ear). The guinea pigs were slaughtered and their temporal bones were prepared for macroscopic and histological analysis. RESULTS: The macroscopic findings had evidenced the presence of cholesteatoma in 25% of the right ears and 85% of the left ears (P=0.0003 *). The histological study had evidenced the presence of cholesteatoma in 30% of right ears and 75% of the left ears (P=0.0104*). CONCLUSION: The local use of the trans-retinoic acid is effective in inhibiting the induced formation of cholesteatomas in guinea pigs.
Marcos Luiz Antunes; Yotaka Fukuda; Norma de Oliveira Penido; Rimarcs Ferreira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brazilian journal of otorhinolaryngology     Volume:  74     ISSN:  1808-8694     ISO Abbreviation:  -     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-08-07     Revised Date:  2008-10-06    
Medline Journal Info:
Nlm Unique ID:  101207337     Medline TA:  Braz J Otorhinolaryngol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  IM    
Faculdade de medicina do ABC, SP, Brazil.
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MeSH Terms
Administration, Cutaneous
Antineoplastic Agents / therapeutic use*
Cholesteatoma, Middle Ear / chemically induced,  pathology,  prevention & control*
Disease Models, Animal
Guinea Pigs
Propylene Glycol*
Prospective Studies
Tretinoin / therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents; 302-79-4/Tretinoin; 57-55-6/Propylene Glycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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