| Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. | |
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MedLine Citation:
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PMID: 18276898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal muscle gene response to exercise depends on nutritional status during and after exercise, but it is unknown whether muscle adaptations to endurance training are affected by nutritional status during training sessions. Therefore, this study investigated the effect of an endurance training program (6 wk, 3 day/wk, 1-2 h, 75% of peak Vo(2)) in moderately active males. They trained in the fasted (F; n = 10) or carbohydrate-fed state (CHO; n = 10) while receiving a standardized diet [65 percent of total energy intake (En) from carbohydrates, 20%En fat, 15%En protein]. Before and after the training period, substrate use during a 2-h exercise bout was determined. During these experimental sessions, all subjects were in a fed condition and received extra carbohydrates (1 g.kg body wt(-1) .h(-1)). Peak Vo(2) (+7%), succinate dehydrogenase activity, GLUT4, and hexokinase II content were similarly increased between F and CHO. Fatty acid binding protein (FABPm) content increased significantly in F (P = 0.007). Intramyocellular triglyceride content (IMCL) remained unchanged in both groups. After training, pre-exercise glycogen content was higher in CHO (545 +/- 19 mmol/kg dry wt; P = 0.02), but not in F (434 +/- 32 mmol/kg dry wt; P = 0.23). For a given initial glycogen content, F blunted exercise-induced glycogen breakdown when compared with CHO (P = 0.04). Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits similar adaptations in peak Vo(2) whether carried out in the fasted or carbohydrate-fed state. Although there was a decrease in exercise-induced glycogen breakdown and an increase in proteins involved in fat handling after fasting training, fat oxidation during exercise with carbohydrate intake was not changed. |
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Authors:
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K De Bock; W Derave; B O Eijnde; M K Hesselink; E Koninckx; A J Rose; P Schrauwen; A Bonen; E A Richter; P Hespel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-14 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 104 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-03 Completed Date: 2008-06-17 Revised Date: 2009-06-24 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1045-55 Citation Subset: IM |
Affiliation:
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Research Center for Exercise and Health, F.A.B.E.R. - K.U.Leuven, Tervuursevest 101, B-3001 Leuven Heverlee, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Blotting, Western Body Weight Dietary Carbohydrates / pharmacology* Exercise / physiology* Fasting / physiology* Fats / metabolism Hormones / blood Humans Image Processing, Computer-Assisted Kinetics Male Metabolism / physiology* Muscle, Skeletal / drug effects, metabolism Oxygen Consumption / drug effects, physiology Physical Fitness / physiology* RNA / biosynthesis Reverse Transcriptase Polymerase Chain Reaction Reverse Transcription Succinate Dehydrogenase / metabolism Tissue Fixation |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 0/Fats; 0/Hormones; 63231-63-0/RNA; EC 1.3.99.1/Succinate Dehydrogenase |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 2009 Jun;106(6):1757-8
[PMID:
19359614
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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