Document Detail


Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake.
MedLine Citation:
PMID:  18276898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skeletal muscle gene response to exercise depends on nutritional status during and after exercise, but it is unknown whether muscle adaptations to endurance training are affected by nutritional status during training sessions. Therefore, this study investigated the effect of an endurance training program (6 wk, 3 day/wk, 1-2 h, 75% of peak Vo(2)) in moderately active males. They trained in the fasted (F; n = 10) or carbohydrate-fed state (CHO; n = 10) while receiving a standardized diet [65 percent of total energy intake (En) from carbohydrates, 20%En fat, 15%En protein]. Before and after the training period, substrate use during a 2-h exercise bout was determined. During these experimental sessions, all subjects were in a fed condition and received extra carbohydrates (1 g.kg body wt(-1) .h(-1)). Peak Vo(2) (+7%), succinate dehydrogenase activity, GLUT4, and hexokinase II content were similarly increased between F and CHO. Fatty acid binding protein (FABPm) content increased significantly in F (P = 0.007). Intramyocellular triglyceride content (IMCL) remained unchanged in both groups. After training, pre-exercise glycogen content was higher in CHO (545 +/- 19 mmol/kg dry wt; P = 0.02), but not in F (434 +/- 32 mmol/kg dry wt; P = 0.23). For a given initial glycogen content, F blunted exercise-induced glycogen breakdown when compared with CHO (P = 0.04). Neither IMCL breakdown (P = 0.23) nor fat oxidation rates during exercise were altered by training. Thus short-term training elicits similar adaptations in peak Vo(2) whether carried out in the fasted or carbohydrate-fed state. Although there was a decrease in exercise-induced glycogen breakdown and an increase in proteins involved in fat handling after fasting training, fat oxidation during exercise with carbohydrate intake was not changed.
Authors:
K De Bock; W Derave; B O Eijnde; M K Hesselink; E Koninckx; A J Rose; P Schrauwen; A Bonen; E A Richter; P Hespel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-14
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-06-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1045-55     Citation Subset:  IM    
Affiliation:
Research Center for Exercise and Health, F.A.B.E.R. - K.U.Leuven, Tervuursevest 101, B-3001 Leuven Heverlee, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Blotting, Western
Body Weight
Dietary Carbohydrates / pharmacology*
Exercise / physiology*
Fasting / physiology*
Fats / metabolism
Hormones / blood
Humans
Image Processing, Computer-Assisted
Kinetics
Male
Metabolism / physiology*
Muscle, Skeletal / drug effects,  metabolism
Oxygen Consumption / drug effects,  physiology
Physical Fitness / physiology*
RNA / biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Reverse Transcription
Succinate Dehydrogenase / metabolism
Tissue Fixation
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Fats; 0/Hormones; 63231-63-0/RNA; EC 1.3.99.1/Succinate Dehydrogenase
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2009 Jun;106(6):1757-8   [PMID:  19359614 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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