| Effect of a toxin isolated from the sponge Haliclona viridis on the release of gamma-aminobutyric acid from rat olfactory bulb. | |
| | |
MedLine Citation:
|
PMID: 8389066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A partially purified toxin from the marine sponge Haliclona viridis was studied for its effect on the presynaptic release mechanism of 3H-gamma-aminobutyric acid from nerve terminals of the external plexiform layer of rat olfactory bulb. Previously, the toxin of H. viridis was shown to block the resting potassium conductance in frog muscle. In the present study, the toxin induced a reversible release of 3H-gamma-aminobutyric acid in the external plexiform layer. This effect was similar to that induced by 25 mM K+. The toxin-induced outflow of 3H-gamma-aminobutyric acid was concentration dependent. The action of the toxin was specific for gamma-aminobutyric acid secretion from the external plexiform layer, and dopamine liberation from the frontal cortex; the toxin did not release 3H-valine, a non-neurotransmitter amino acid, from the external plexiform layer. Toxin- and high K(+)-induced neurotransmitter release were both drastically reduced when Ca2+ was removed from the saline. The addition of 0.3 microM tetrodotoxin or the removal of Na+ from the saline did not reduce the toxin's ability to release neurotransmitters. The effect of toxin was enhanced by the addition of valinomycin. Although Haliclona toxin and 4-aminopyridine induced the release of neurotransmitters, they antagonized each other's effect on gamma-aminobutyric acid secretion when added simultaneously. |
| | |
Authors:
|
E Jaffé; M Eisig; C Sevcik |
Related Documents
:
|
1078986 - Glutamic acid, gaba and their metabolising enzymes in the frog central nervous system. 15704886 - Templating photodimerization of trans-cinnamic acids with cucurbit[8]uril and gamma-cyc... 11058166 - Potentiation of pathogen-specific defense mechanisms in arabidopsis by beta -aminobutyr... 2556076 - Structure-epileptogenicity relationship of quinolones with special reference to their i... 1616946 - Gadolinium complexes of [(myristoyloxy)propyl]diethylenetriaminetetraacetate: new lipop... 10594816 - An ordered reaction mechanism for bacterial toxin acylation by the specialized acyltran... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Toxicon : official journal of the International Society on Toxinology Volume: 31 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 1993 Apr |
Date Detail:
|
Created Date: 1993-06-28 Completed Date: 1993-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1307333 Medline TA: Toxicon Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 385-96 Citation Subset: IM |
Affiliation:
|
Laboratory of Neurochemistry, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
4-Aminopyridine
/
pharmacology Animals Calcium / metabolism Dopamine / metabolism Male Marine Toxins / isolation & purification, pharmacology* Membranes / drug effects Olfactory Bulb / drug effects, metabolism* Porifera / chemistry* Potassium / pharmacology Rats Rats, Sprague-Dawley Sodium Channels / drug effects Valinomycin / pharmacology gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Marine Toxins; 0/Sodium Channels; 2001-95-8/Valinomycin; 504-24-5/4-Aminopyridine; 56-12-2/gamma-Aminobutyric Acid; 7440-09-7/Potassium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pain, pain assessment and analgesia in newborn infants
Next Document: Pharmacokinetics of ganciclovir in heart transplant patients undergoing continuous venovenous hemodi...