Document Detail


Effect of total parenteral nutrition on free fatty acid metabolism in burned patients.
MedLine Citation:
PMID:  6431122     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Free fatty acid (FFA) and energy metabolism were studied in six severely burned humans after an 8-hr fast, after 1 hr of total parenteral nutrition, and after 72 hr of uninterrupted total parenteral nutrition. Caloric intake was twice the predicted basal metabolic rate, with 5 mg kg-1 min-1 of glucose, 2.5 g kg-1 day-1 of amino acid and the remainder of calories supplied as a fat emulsion. 1,2-13C-palmitate bound to albumin was continuously infused in order to quantitate FFA turnover and oxidation. Endogenous FFA turnover and oxidation were markedly suppressed by parenteral feeding, presumably due to increased insulin release. A modest recovery occurred in the initial suppression of FFA oxidation after 72 hr, but not in FFA turnover. Fat emulsion provided about one-quarter of the energy released during parenteral feeding, with endogenous FFA oxidation as the major component. This was roughly equivalent to the percentage of calories supplied as fat. This work indicates that the direct oxidation of a lipid emulsion contributes only a small amount of energy released in the setting of the severely traumatized human receiving total parenteral nutrition but serves mainly to preserve endogenous fat stores.
Authors:
R D Goodenough; R R Wolfe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  8     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-14     Completed Date:  1984-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Burns / metabolism*,  therapy
Carbon Isotopes
Child
Energy Intake
Energy Metabolism
Fat Emulsions, Intravenous / metabolism
Fatty Acids, Nonesterified / metabolism*
Female
Humans
Male
Oxidation-Reduction
Palmitates / diagnostic use
Parenteral Nutrition*
Parenteral Nutrition, Total*
Time Factors
Grant Support
ID/Acronym/Agency:
GM 21700-07/GM/NIGMS NIH HHS; GM07035-06/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Palmitates

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