Document Detail

Effect of topical timolol maleate on exercise performance.
MedLine Citation:
PMID:  6385935     Owner:  NLM     Status:  MEDLINE    
The effect of topical timolol maleate on exercise performance was investigated in a randomized double-blind study. Healthy young subjects underwent two graded maximal exercise evaluations on a treadmill. The evaluations were given one week apart. Before each trial, the subjects were given a single drop of either placebo or 0.5% timolol maleate in each eye. The results indicate that topical timolol has a statistically significant effect on both maximal heart rate and time to exhaustion. However, we found that the drug had no effect on the physiologic parameters of Vo2, respiratory rate, Vco2, or respiratory quotient.
W J Doyle; P A Weber; R H Meeks
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  102     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1517-8     Citation Subset:  AIM; IM; S    
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MeSH Terms
Administration, Topical
Clinical Trials as Topic
Double-Blind Method
Exercise Test
Heart Rate / drug effects
Physical Exertion / drug effects*
Random Allocation
Respiration / drug effects
Timolol / administration & dosage*
Reg. No./Substance:
0/Placebos; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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