Document Detail

Effect of topical nipradilol on retinal microvascular leukocyte adhesion in diabetic rats.
MedLine Citation:
PMID:  16974127     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Retinal leukostasis plays an important role in the pathogenesis of diabetic retinopathy.
OBJECTIVES: We studied the effects of nipradilol, a topical antiglaucoma alphabeta-blocker and nitric oxide donor, on the retinal vascular leukocyte adhesion of rats with diabetes.
METHODS: Diabetes was induced in seven Brown-Norway rats by one intravenous injection (65 mg/kg) of streptozotocin and confirmed by blood glucose levels >350 mg/dl 48 h after the injection. Nipradilol solution was instilled in the right eye and nipradilol-free base solution in the left eye for 3 weeks, after which the retinal microcirculation was evaluated by acridine orange leukocyte digital fluorography using laser scanning ophthalmoscopy. Leukocytes trapped in the retina were counted around the optic disc in a 5-disc-diameter area and compared between the right and the left eye.
RESULTS: The mean retinal leukostasis count in the nipradilol-treated eyes (19 +/- 15 cells) was significantly lower than in the untreated eyes (49 +/- 19 cells; p < 0.0008). The diameter of the retinal artery in the eyes treated with nipradilol significantly increased (111 +/- 13.5%) compared with untreated eyes (p < 0.03).
CONCLUSIONS: Topical nipradilol significantly reduced retinal leukostasis in the retinal microcirculation in diabetic rats and may be a prophylactic agent for early diabetic retinopathy through its nitric oxide donor effects on the microcirculation.
Ryuichiro Ono; Akihiro Kakehashi; Yuka Ito; Norito Sugi; Shinji Makino; Eiji Kobayashi; Yoji Hakamada; Yasuhiro Takagi; Yusuke Kitazume; Masanobu Kawakami
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Publication Detail:
Type:  Journal Article     Date:  2006-09-15
Journal Detail:
Title:  Ophthalmic research     Volume:  38     ISSN:  0030-3747     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-29     Completed Date:  2006-11-02     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  270-3     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 S. Karger AG, Basel.
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MeSH Terms
Administration, Topical
Adrenergic alpha-Antagonists / administration & dosage*,  pharmacology
Adrenergic beta-Antagonists / administration & dosage*,  pharmacology
Cell Adhesion / drug effects*
Diabetes Mellitus, Experimental / physiopathology
Diabetic Retinopathy / physiopathology*
Fluorescein Angiography
Leukocyte Count
Leukocytes / physiology*
Leukostasis / drug therapy,  physiopathology
Nitric Oxide / metabolism
Nitric Oxide Donors / administration & dosage,  pharmacology
Ophthalmic Solutions / administration & dosage,  pharmacology
Propanolamines / administration & dosage*,  pharmacology
Rats, Inbred BN
Retinal Artery / physiology*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Nitric Oxide Donors; 0/Ophthalmic Solutions; 0/Propanolamines; 31C4KY9ESH/Nitric Oxide; FVM336I71Y/nipradilol

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