| Effect of topical interferon-beta on recurrence rates in genital herpes: a double-blind, placebo-controlled, randomized study. | |
| | |
MedLine Citation:
|
PMID: 7553233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this randomized, double-blind placebo-controlled trial was to evaluate the effect of IFN-beta cream applied at the time of recurrent eruptions of genital herpes during 6 months on the overall rate of recurrence. Therapy was initiated at the clinic for the first treated recurrence, and thereafter by the patient for early treatment of eventual subsequent eruptions. Each recurrence was ascertained at the clinic in all 35 evaluable patients. The mean recurrence rate was significantly lower in the group using IFN-beta cream than in the placebo group (p = 0.03). Complete responders without recurrence for the duration of the trial were 36.4% of all patients and 46% among women versus 15.4 and 16.6% in the placebo groups, respectively. A total of 77.3% of all patients were defined as complete or partial responders, their average recurrences/year decreasing from 11 to 2.2 (p < 0.0001). The topical episodic IFN-beta treatment was well tolerated by patients and without side effects. It is concluded that IFN-beta cream application reduces the overall rate of recurrence of genital herpes. |
| | |
Authors:
|
J Ophir; S Brenner; R Bali; S Kriss-Leventon; Z Smetana; M Revel |
Related Documents
:
|
19567163 - Prolonged chronic phase in chronic myelogenous leukemia after homoharringtonine therapy. 12048063 - Randomized, controlled trial of natural interferon-alpha therapy for e-antigen-positive... 18370463 - Pharmacoeconomic assessment of olanzapine in the treatment of refractory schizophrenia ... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: 15 ISSN: 1079-9907 ISO Abbreviation: J. Interferon Cytokine Res. Publication Date: 1995 Jul |
Date Detail:
|
Created Date: 1995-11-22 Completed Date: 1995-11-22 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 625-31 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, Tel Aviv Medical Center, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Adult Antiviral Agents / therapeutic use* Double-Blind Method Evaluation Studies as Topic Female Herpes Genitalis / drug therapy* Humans Interferon-beta / therapeutic use* Male Placebos Recurrence |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Placebos; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interleukin-1 enhances indoleamine 2,3-dioxygenase activity by increasing specific mRNA expression i...
Next Document: Interferon-gamma detection in cultures of newborn cells exposed to Listeria monocytogenes.