Document Detail


Effect of topical interferon-beta on recurrence rates in genital herpes: a double-blind, placebo-controlled, randomized study.
MedLine Citation:
PMID:  7553233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this randomized, double-blind placebo-controlled trial was to evaluate the effect of IFN-beta cream applied at the time of recurrent eruptions of genital herpes during 6 months on the overall rate of recurrence. Therapy was initiated at the clinic for the first treated recurrence, and thereafter by the patient for early treatment of eventual subsequent eruptions. Each recurrence was ascertained at the clinic in all 35 evaluable patients. The mean recurrence rate was significantly lower in the group using IFN-beta cream than in the placebo group (p = 0.03). Complete responders without recurrence for the duration of the trial were 36.4% of all patients and 46% among women versus 15.4 and 16.6% in the placebo groups, respectively. A total of 77.3% of all patients were defined as complete or partial responders, their average recurrences/year decreasing from 11 to 2.2 (p < 0.0001). The topical episodic IFN-beta treatment was well tolerated by patients and without side effects. It is concluded that IFN-beta cream application reduces the overall rate of recurrence of genital herpes.
Authors:
J Ophir; S Brenner; R Bali; S Kriss-Leventon; Z Smetana; M Revel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research     Volume:  15     ISSN:  1079-9907     ISO Abbreviation:  J. Interferon Cytokine Res.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-22     Completed Date:  1995-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9507088     Medline TA:  J Interferon Cytokine Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-31     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Tel Aviv Medical Center, Israel.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Antiviral Agents / therapeutic use*
Double-Blind Method
Evaluation Studies as Topic
Female
Herpes Genitalis / drug therapy*
Humans
Interferon-beta / therapeutic use*
Male
Placebos
Recurrence
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Placebos; 77238-31-4/Interferon-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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