| Effect of topical diclofenac and ketorolac on patient discomfort and corneal sensitivity. | |
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MedLine Citation:
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PMID: 11934203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine if at clinical dosages, the topical nonsteroidal anti-inflammatory drugs diclofenac and ketorolac decrease corneal sensitivity, and if there is a difference in discomfort on instillation. METHODS: In a double-masked study, 30 patients were randomized to receive two of three topical drops, Endosol, diclofenac sodium, and ketorolac tromethamine. A microaesthesiometer was used to evaluate corneal sensation. Baseline corneal sensitivity was obtained on each patient. Corneal sensory thresholds were remeasured at 7 and 15 minutes following eyedrop application. Patients also completed a questionnaire that graded the burning caused by the medications. RESULTS: No significant decrease in corneal sensory thresholds was found with diclofenac or ketorolac compared with control at baseline (P = .50), 7 minutes (P = .41), or 15 minutes (P = .82). There was significantly more burning with diclofenac and ketorolac compared to control. There was a small but not statistically significant (P = .28) trend of more burning with ketorolac than diclofenac. CONCLUSION: Neither diclofenac nor ketorolac were found to decrease corneal sensation compared to control. There was no significant difference in burning upon instillation reported by patients. |
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Authors:
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Julio Narváez; Peter Kroll; James P Guzek |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of refractive surgery (Thorofare, N.J. : 1995) Volume: 18 ISSN: 1081-597X ISO Abbreviation: J Refract Surg Publication Date: 2002 Mar-Apr |
Date Detail:
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Created Date: 2002-04-05 Completed Date: 2002-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505927 Medline TA: J Refract Surg Country: United States |
Other Details:
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Languages: eng Pagination: 145-8 Citation Subset: IM |
Affiliation:
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Turlock Eye Physicians Medical Group, CA, USA. narvaez@evestamail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacology* Cornea / drug effects, physiology* Diclofenac / administration & dosage, pharmacology* Double-Blind Method Female Humans Ketorolac Tromethamine / administration & dosage, pharmacology* Male Middle Aged Ophthalmic Solutions Patient Satisfaction Sensation / drug effects* Sensory Thresholds / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 74103-07-4/Ketorolac Tromethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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