Document Detail

Effect of topical diclofenac and ketorolac on patient discomfort and corneal sensitivity.
MedLine Citation:
PMID:  11934203     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine if at clinical dosages, the topical nonsteroidal anti-inflammatory drugs diclofenac and ketorolac decrease corneal sensitivity, and if there is a difference in discomfort on instillation. METHODS: In a double-masked study, 30 patients were randomized to receive two of three topical drops, Endosol, diclofenac sodium, and ketorolac tromethamine. A microaesthesiometer was used to evaluate corneal sensation. Baseline corneal sensitivity was obtained on each patient. Corneal sensory thresholds were remeasured at 7 and 15 minutes following eyedrop application. Patients also completed a questionnaire that graded the burning caused by the medications. RESULTS: No significant decrease in corneal sensory thresholds was found with diclofenac or ketorolac compared with control at baseline (P = .50), 7 minutes (P = .41), or 15 minutes (P = .82). There was significantly more burning with diclofenac and ketorolac compared to control. There was a small but not statistically significant (P = .28) trend of more burning with ketorolac than diclofenac. CONCLUSION: Neither diclofenac nor ketorolac were found to decrease corneal sensation compared to control. There was no significant difference in burning upon instillation reported by patients.
Julio Narváez; Peter Kroll; James P Guzek
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of refractive surgery (Thorofare, N.J. : 1995)     Volume:  18     ISSN:  1081-597X     ISO Abbreviation:  J Refract Surg     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-04-05     Completed Date:  2002-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505927     Medline TA:  J Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Turlock Eye Physicians Medical Group, CA, USA.
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology*
Cornea / drug effects,  physiology*
Diclofenac / administration & dosage,  pharmacology*
Double-Blind Method
Ketorolac Tromethamine / administration & dosage,  pharmacology*
Middle Aged
Ophthalmic Solutions
Patient Satisfaction
Sensation / drug effects*
Sensory Thresholds / drug effects
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 74103-07-4/Ketorolac Tromethamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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