Document Detail

Effect of topical corticosteroids on goblet-cell density in an alkali-burn model.
MedLine Citation:
PMID:  1746815     Owner:  NLM     Status:  MEDLINE    
Conjunctival alkali burns result in a loss of goblet cells in the acute postinjury period. A deficiency of goblet cells and their primary product, mucin, is associated with both short- and long-term ocular sequelas. We evaluated the effect of topical corticosteroids on goblet-cell density in a prospective, randomized, controlled trial using 24 eyes of 12 adult albino rabbits in which a standard conjunctival burn was made. The treatment group was found to have 97.38 goblet cells per unit area of conjunctiva; the control group had 65.81 goblet cells per unit area of conjunctiva. This was a statistically significant difference (P less than .02). These results suggest that topical steroids are beneficial in suppressing goblet-cell loss after a conjunctival alkali burn.
B D Brent; Z A Karcioglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of ophthalmology     Volume:  23     ISSN:  0003-4886     ISO Abbreviation:  Ann Ophthalmol     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-01-16     Completed Date:  1992-01-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0210137     Medline TA:  Ann Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM    
Dept. of Ophthalmology, Tulane University Medical Center, New Orleans, LA 70130.
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MeSH Terms
Administration, Topical
Burns, Chemical / drug therapy*
Cell Count
Conjunctiva / pathology*
Disease Models, Animal
Eye Burns / chemically induced,  pathology*
Prednisolone / analogs & derivatives*,  pharmacology
Prospective Studies
Random Allocation
Sodium Hydroxide
Reg. No./Substance:
1310-73-2/Sodium Hydroxide; 302-25-0/prednisolone phosphate; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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