Document Detail

Effect of topical applications of a novel chlorhexidine-thymol varnish formula on mutans streptococci and caries development in occlusal fissures of permanent molars.
MedLine Citation:
PMID:  20128319     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of a new formula of a chlorhexidine-thymol varnish on mutans streptococci (MS) colonization and fissure caries development. METHODS: The study group consisted of 58 healthy adolescents (12-17 years old) undergoing orthodontic treatment with fixed appliances. A double-blind split-mouth design was applied, and 116 pairs of molar teeth were randomly assigned to topical varnish applications with either the new Cervitec Plus or its predecessor Cervitec. Both varnishes contained 1% CHX and 1% thymol (CHX/T) as active ingredients, but differed with respect to adhesive properties. The varnishes were applied in the fissures at baseline, and then every sixth week throughout the 48-week study period. Endpoints were MS colonization (CRT test) and occlusal laser fluorescence (LF, DIAGNOdent) recordings carried out regularly during follow-up. RESULTS: A significant reduction in the levels of MS in the fissures after the initial treatment was displayed with both varnishes (p < 0.05), and the levels remained consistently suppressed throughout the follow-up period. A non-significant but clear tendency was noted in favor of the new formula after six and 12 weeks, with fewer teeth harboring high counts (> or = 10(5) CFU) of MS (6w:12% vs. 24%, 12w:16% vs. 26%). No new lesions were registered in any subject, and the mean LF recordings did not change significantly over time in the groups. CONCLUSION: There were no statistically significant differences between the CHX/T varnishes in terms of bacterial growth and caries prevention. For MS suppression, a tendency towards an initially superior effect was displayed with the new formula.
Kerstin Sköld-Larsson; Ola Sollenius; Lars G Petersson; Svante Twetman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical dentistry     Volume:  20     ISSN:  0895-8831     ISO Abbreviation:  J Clin Dent     Publication Date:  2009  
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-03-12     Revised Date:  2010-07-22    
Medline Journal Info:
Nlm Unique ID:  8904411     Medline TA:  J Clin Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  D    
Department of Orthodontics, County Hospital, Halmstad, Sweden.
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MeSH Terms
Anti-Infective Agents, Local / administration & dosage,  pharmacology*
Cariostatic Agents / administration & dosage,  pharmacology*
Chlorhexidine / administration & dosage,  pharmacology
Colony Count, Microbial
Dental Caries Activity Tests
Dental Fissures / microbiology*,  prevention & control*
Double-Blind Method
Drug Combinations
Lasers, Solid-State / diagnostic use
Molar / microbiology
Orthodontic Appliances
Streptococcus mutans / drug effects*
Thymol / administration & dosage,  pharmacology
Reg. No./Substance:
0/Adhesives; 0/Anti-Infective Agents, Local; 0/Cariostatic Agents; 0/Drug Combinations; 0/chlorhexidine, thymol drug combination; 55-56-1/Chlorhexidine; 89-83-8/Thymol

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