Document Detail

Effect of topical application of coenzyme Q10 on adult periodontitis.
MedLine Citation:
PMID:  7752836     Owner:  NLM     Status:  MEDLINE    
Topical application of Coenzyme Q10 (CoQ10) to the periodontal pocket was evaluated with and without subgingival mechanical debridement. Ten male patients with adult periodontitis participated and 30 periodontal pockets were selected. During the first 3 weeks, the patients did not receive any periodontal therapy except the topical application of CoQ10. After the first 3-week period, root planning and subgingival scaling were performed in all sites. CoQ10 was applied in 20 of the pockets once a week for a period of 6 weeks. Soybean oil was applied to the remaining 10 sites as a control. In the first 3-week period, significant reductions in gingival crevicular fluid flow, probing depth and attachment loss were found only at experimental sites. After mechanical subgingival debridement, significant decreases in the plaque index, gingival crevicular fluid flow, probing depth and attachment loss were found both at experimental and control sites. However, significant improvements in the modified gingival index, bleeding on probing and peptidase activity derived from periodontopathic bacteria were observed only at experimental sites. These results suggest that topical application of CoQ10 improves adult periodontitis not only as a sole treatment but also in combination with traditional nonsurgical periodontal therapy.
T Hanioka; M Tanaka; M Ojima; S Shizukuishi; K Folkers
Related Documents :
17544316 - Effect of reactor's positions on polymerization and degradation in an ultrasonic field.
24821406 - A candidate syntenic genetic locus is associated with voluntary exercise levels in mice...
18412726 - Effects of fixed orthodontic appliances on subgingival microflora.
18254046 - Surgical hand antisepsis to reduce surgical site infection.
17951966 - Differential effects of aging, drinking and exercise on serum cholesterol levels depend...
16040636 - Isoflurane does not mimic ischaemic preconditioning in decreasing hydroxyl radical prod...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  15 Suppl     ISSN:  0098-2997     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:  1994  
Date Detail:
Created Date:  1995-06-21     Completed Date:  1995-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  s241-8     Citation Subset:  IM    
Department of Preventive Dentistry, Osaka University Faculty of Dentistry, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Topical
Bacteria / isolation & purification
Combined Modality Therapy
Dental Plaque Index
Dental Scaling
Middle Aged
Periodontal Index
Periodontitis / drug therapy*,  microbiology,  therapy
Pilot Projects
Root Planing
Treatment Outcome
Ubiquinone / administration & dosage,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional an...
Next Document:  Coenzyme Q10 levels in human seminal fluid: diagnostic and clinical implications.