| Effect of topical application of coenzyme Q10 on adult periodontitis. | |
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MedLine Citation:
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PMID: 7752836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Topical application of Coenzyme Q10 (CoQ10) to the periodontal pocket was evaluated with and without subgingival mechanical debridement. Ten male patients with adult periodontitis participated and 30 periodontal pockets were selected. During the first 3 weeks, the patients did not receive any periodontal therapy except the topical application of CoQ10. After the first 3-week period, root planning and subgingival scaling were performed in all sites. CoQ10 was applied in 20 of the pockets once a week for a period of 6 weeks. Soybean oil was applied to the remaining 10 sites as a control. In the first 3-week period, significant reductions in gingival crevicular fluid flow, probing depth and attachment loss were found only at experimental sites. After mechanical subgingival debridement, significant decreases in the plaque index, gingival crevicular fluid flow, probing depth and attachment loss were found both at experimental and control sites. However, significant improvements in the modified gingival index, bleeding on probing and peptidase activity derived from periodontopathic bacteria were observed only at experimental sites. These results suggest that topical application of CoQ10 improves adult periodontitis not only as a sole treatment but also in combination with traditional nonsurgical periodontal therapy. |
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Authors:
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T Hanioka; M Tanaka; M Ojima; S Shizukuishi; K Folkers |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Molecular aspects of medicine Volume: 15 Suppl ISSN: 0098-2997 ISO Abbreviation: Mol. Aspects Med. Publication Date: 1994 |
Date Detail:
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Created Date: 1995-06-21 Completed Date: 1995-06-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603128 Medline TA: Mol Aspects Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: s241-8 Citation Subset: IM |
Affiliation:
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Department of Preventive Dentistry, Osaka University Faculty of Dentistry, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Bacteria / isolation & purification Coenzymes Combined Modality Therapy Dental Plaque Index Dental Scaling Humans Male Middle Aged Periodontal Index Periodontitis / drug therapy*, microbiology, therapy Pilot Projects Root Planing Treatment Outcome Ubiquinone / administration & dosage, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Coenzymes; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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