Document Detail

Effect of topical anesthesia of the laryngeal mucosa on upper airway mechanics in exercising horses.
MedLine Citation:
PMID:  11703011     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of desensitization of the laryngeal mucosal mechanoreceptors on upper airway mechanics in exercising horses. ANIMALS: 6 Standardbreds. PROCEDURE: In study 1, videoendoscopic examinations were performed while horses ran on a treadmill with and without topical anesthesia of the laryngeal mucosa. In study 2, peak tracheal and nasopharyngeal pressures and airflows were obtained from horses during incremental treadmill exercise tests, with and without topical anesthesia of the laryngeal mucosa. A nasal occlusion test was performed on each horse while standing during an endoscopic examination for both trials. RESULTS: In study 1, horses had nasopharyngeal collapse while running on the treadmill when the laryngeal mucosa was anesthetized. In study 2, inspiratory upper airway and nasopharyngeal impedance were significantly higher, and peak tracheal inspiratory pressure, respiratory frequency, and minute ventilation were significantly lower in horses when the laryngeal mucosa was anesthetized, compared with values obtained when horses exercised without topical anesthesia. Peak inspiratory and expiratory airflows were lower in horses when the laryngeal mucosa was anesthetized, although differences did not quite reach significance (P = 0.06 and 0.09, respectively). During a nasal occlusion test, horses had episodes of nasopharyngeal collapse and dorsal displacement of the soft palate when the laryngeal mucosa was anesthetized. Upper airway function was normal in these horses without laryngeal mucosal anesthesia. CONCLUSIONS AND CLINICAL RELEVANCE: Receptors within the laryngeal mucosa may be important in maintaining upper airway patency in exercising horses.
S J Holcombe; F J Derksen; C Berney; A C Becker; N T Horner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  62     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-04-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1706-10     Citation Subset:  IM    
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48624, USA.
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MeSH Terms
Administration, Topical
Anesthetics, Local / administration & dosage,  pharmacology*
Endoscopy / veterinary
Horses / physiology*
Laryngeal Mucosa / drug effects*,  physiology
Mechanoreceptors / physiology
Mepivacaine / administration & dosage,  pharmacology*
Physical Conditioning, Animal / physiology
Pulmonary Ventilation / drug effects
Random Allocation
Respiration / drug effects*
Reg. No./Substance:
0/Anesthetics, Local; 96-88-8/Mepivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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