Document Detail

Effect of topical anaesthesia on corneal epithelial fragility.
MedLine Citation:
PMID:  6480223     Owner:  NLM     Status:  MEDLINE    
The effect of topical anaesthetics on human corneal integrity was assessed by measurement of the alterations they cause in corneal damage threshold. The anaesthetics investigated were 1.0% Amethocaine HCl, assessed immediately after instillation and after delays of 20 min and 60 min, and 0.5% Amethocaine HCl and 0.4% Benoxinate HCl, assessed 20 min after instillation. At 20 min after instillation of 1.0% Amethocaine HCl, the corneal damage threshold was significantly decreased. At other times for this anaesthetic, and for 0.5% Amethocaine HCl and 0.4% Benoxinate HCl, the corneal damage threshold was unaltered.
L G Carney; D J O'Leary; M Millodot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International ophthalmology     Volume:  7     ISSN:  0165-5701     ISO Abbreviation:  Int Ophthalmol     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-11-21     Completed Date:  1984-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7904294     Medline TA:  Int Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
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MeSH Terms
Anesthetics, Local / toxicity*
Cornea / drug effects*
Epithelium / drug effects
Procaine / analogs & derivatives*,  toxicity
Tetracaine / toxicity*
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 59-46-1/Procaine; 94-24-6/Tetracaine; 99-43-4/benoxinate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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