| Effect of tolbutamide on myocardial energy metabolism of the ischemic heart. | |
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MedLine Citation:
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PMID: 3977956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The oral hypoglycemic agent tolbutamide has been found to protect the ischemic myocardium against irreversible mechanical failure. The possibility that this salutary effect of tolbutamide was related to its ability to alter energy metabolism was examined in ischemic rat hearts perfused with 5 mM glucose, 5mM acetate and 2.5 units/l insulin. In the presence of 0.6 mM tolbutamide, coronary flow and oxygen consumption were unaltered; however, glucose utilization was stimulated by 30%, glycogenolysis was enhanced by 23%, and the drop in ATP content was reduced by 17% after 30 min, of low-flow perfusion. This elevation in glycolytic flux occurred without a parallel rise in the production of inhibitory metabolites; lactate production was unaltered and tissue lactate/pyruvate ratio decreased. Pyruvate dehydrogenase flux measurements reveal that the mechanism by which tolbutamide increases glycolysis without increasing lactate production is by promoting the entry of pyruvate into the mitochondria. The basis for the observed stimulation of anaerobic metabolism and pyruvate oxidation and how this contributes to the increase in ATP content and benefits the ischemic heart is discussed. |
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Authors:
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W G Lampson; J H Kramer; S W Schaffer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical pharmacology Volume: 34 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-17 Completed Date: 1985-04-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 803-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Coronary Circulation / drug effects Coronary Disease / metabolism* Energy Metabolism / drug effects* Glucose / metabolism Glycogen / metabolism Male Myocardium / metabolism* Pyruvates / metabolism Pyruvic Acid Rats Rats, Inbred Strains Tolbutamide / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-28445/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pyruvates; 127-17-3/Pyruvic Acid; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate; 64-77-7/Tolbutamide; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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