Document Detail


Effect of tolamolol and propranolol on exercise heart rate and angina.
MedLine Citation:
PMID:  1173059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifteen patients with angina pectoris participated in a double-blind study evaluating the effect of intravenous saline, 10 mg of intravenous tolamolol, 20 mg of intravenous tolamolol, and 10 mg of intravenous propranolol on resting and exercise heart rate and on exercise time until angina. Twenty mg of tolamolol and 10 mg of propranolol caused a similar decrease in mean resting heart rate, heart rate after a similar amount of exercise, heart rate at angina, resting product of systolic blood pressure times heart rate, and product of systolic blood pressure times heart rate at angina and were, therefore, judged equipotent. Tolamolol, 10 and 20 mg, and propranolol, 10 mg. were not followed by a significant change in mean exercise duration until angina, but there was a 25 percent increase in exercise time until angina in 4 of 15 patients (27 percent) after 10 mg of propranolol and in 3 of 15 patients (20 percent) after 20 mg of tolamolol.
Authors:
W S Aronow; N Spivacek; W Laverty; M Warren
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  17     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-07-02     Completed Date:  1975-07-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Angina Pectoris / physiopathology*
Blood Pressure / drug effects
Electrocardiography
Heart Rate / drug effects*
Humans
Male
Middle Aged
Physical Exertion*
Propanolamines / pharmacology*
Propranolol / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Propanolamines; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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