Document Detail


Effect of tocolytic agents on fetal umbilical velocimetry.
MedLine Citation:
PMID:  2206066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this prospective study, we sought to examine the changes in umbilical vascular resistance induced by tocolytic therapy. Umbilical artery velocimetry was performed in 46 patients with preterm labor before tocolysis and at 1 hour and 24 hours after tocolysis was initiated. Raw systolic/diastolic ratios were corrected for concomitant changes in fetal heart rate. Thirty patients received subcutaneous terbutaline and 16 were treated with intravenous magnesium. Systolic/diastolic ratios decreased in patients treated with terbutaline. This decline persisted after correction for increases in fetal heart rate. No significant changes in systolic/diastolic ratios were seen in patients treated with magnesium. We conclude that terbutaline may affect umbilical vascular resistance. Possible clinical implications of these findings are discussed.
Authors:
J W Wright; R M Patterson; L E Ridgway; M D Berkus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  163     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-24     Completed Date:  1990-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  748-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Female
Heart Rate, Fetal / drug effects
Humans
Magnesium / pharmacology
Pregnancy
Terbutaline / pharmacology
Tocolytic Agents / pharmacology*
Ultrasonography
Umbilical Arteries / physiology*
Vascular Resistance / drug effects*
Chemical
Reg. No./Substance:
0/Tocolytic Agents; 23031-25-6/Terbutaline; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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