Document Detail


Effect of tin and lead chlorotriphenyl analogues on selected living cells.
MedLine Citation:
PMID:  21154756     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Three kinds of living cells, human embryonic kidney cells, Saccharomyces cerevisiae, and Escherichia coli, were tested for their sensitivity to chlorotriphenyltin and chlorotriphenyllead. The tin compound proved definitely more toxic than the lead derivative, particularly in the case of the human embryonic kidney cells devoid of any protective cell wall. Electron paramagnetic resonance (EPR) comparative studies carried out by using a natural model liposome system (egg yolk lecithin) confirmed considerable changes within the lipid bilayer upon doping by the aforementioned additives, which may be crucial to the mechanism of the observed cell cleavage. The individual dopants revealed diverse impact upon the membrane's condition, chlorotriphenyltin distinctly fluidized the lipid system, whereas chlorotriphenyllead stiffened the medium within the membrane. A theoretical approach concerning such different behaviors of studied tin and lead analogues because of their high toxicity in living cells has been presented. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 00:1-7 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20380.
Authors:
Ewa Boniewska-Bernacka; Dariusz Man; Rudolf Słota; Małgorzata A Broda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-10
Journal Detail:
Title:  Journal of biochemical and molecular toxicology     Volume:  -     ISSN:  1099-0461     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9717231     Medline TA:  J Biochem Mol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Biotechnology and Molecular Biology, Opole University, 45-035 Opole, ul. Kominka 4, Poland.
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