Document Detail

Effect of the timing of food intake on the absorption and bioavailability of carbamazepine immediate-release tablets in beagle dogs.
MedLine Citation:
PMID:  22271001     Owner:  NLM     Status:  Publisher    
The effect of dosing time on the bioavailability of carbamazepine immediate-release (IR) tablets was investigated when administrated to beagle dogs who were fasting, with coadministration of food (Co-food), and 0.5 h before food and 2 h after food. The study was conducted using a single dose of 200 mg (tablets/solution) with a 2-week washout period in a crossover design. Food intake significantly increased the rate and extent of tablets absorption. The C(max) (µg·ml(-1) , 8.13/3.65) and t(max) (h, 1.83/0.92) were increased more than twofold and the AUC(0-24) (µg·h·ml(-1) , 20.09/8.19) was 2.5 times that of the values obtained under fasting conditions. The bioavailability of the tablets under fasting conditions was 91.2 %, but increased to 223.5 %, 182.8 % and 148.4% in the Co-food, 0.5 h before food and 2 h after food groups, respectively (p < 0.05). Although there was no significantly difference in the C(max) or AUC(0-24) between the treatments with food, the absorption appeared to be reduced to some extent when the tablets were given 2 h after food. The oral bioavailability of CBZ IR tablets was significantly affected by the timing of the food intake. This is may be favored by the fluctuations in the level of bile salts with the timing of food intake. To obtain acute therapy for a drug with narrow therapeutic window, attention should be given to the dosing time and food intake interactions. Copyright © 2012 John Wiley & Sons, Ltd.
Cai-Hong Xu; Gang Cheng; Yi Liu; Ye Tian; Jing Yan; Mei-Juan Zou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-23
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  -     ISSN:  1099-081X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110016, Liaoning Province, PR China.
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