Document Detail


Effect of timing of energy and carbohydrate replacement on post-exercise insulin action.
MedLine Citation:
PMID:  18059588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nutritional environment surrounding an exercise bout modulates post-exercise insulin action. The purpose of this study was to determine how timing energy and carbohydrate replacement proximate to an exercise bout influences exercise-enhanced insulin action. To create an appropriate baseline, sensitivity to insulin was reduced in 9 healthy young men (n=6) and women (n=3) by 2 days of energy surplus and detraining. Then, insulin action (glucose uptake per unit plasma insulin) was assessed by stable isotope dilution during a continuous glucose infusion 12 h after a standardized meal under 4 conditions. In 3 conditions, the meal replaced the energy and carbohydrate expended during an exercise bout (62.9+/-2.8 min cycle ergometry at 65% VO2 peak followed by ten 30 s sprints). The meal was given before (Pre), immediately after (ImmPost), or 3 h after exercise (Delay). The 4th condition was a no-exercise control (Control). Data were analyzed using linear mixed-effects models with planned contrasts. Relative to Control, insulin action increased by 22% in Pre (p=0.05), 44% in ImmPost (p<0.01), and 19% in Delay (p=0.09). Non-oxidative disposal was higher, and oxidative disposal was lower in ImmPost relative to Control and Pre (p<0.05). Hepatic glucose production was suppressed by the infusion to a greater extent in Pre and Delay (76.9%+/-8.8% and 81.2%+/-4.7%) compared with ImmPost (64.7%+/-10.0%). A bout of exercise enhances insulin action even when expended energy and carbohydrate are replaced. Further, timing of energy and carbohydrate consumption subtly modulates the effectiveness of exercise to enhance insulin action.
Authors:
Brooke R Stephens; Jeffrey M Sautter; Kaila A Holtz; Carrie G Sharoff; Stuart R Chipkin; Barry Braun
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  32     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1139-47     Citation Subset:  IM    
Affiliation:
Energy Metabolism Laboratory, Department of Kinesiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
Algorithms
Anaerobic Threshold
Blood Glucose / metabolism
Body Composition / physiology
Cross-Over Studies
Dietary Carbohydrates / pharmacology*
Energy Intake / physiology*
Energy Metabolism / drug effects,  physiology
Exercise / physiology*
Female
Glycerol / blood
Humans
Insulin / blood,  physiology*
Kinetics
Lipid Metabolism / drug effects,  physiology
Liver / drug effects,  metabolism
Male
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 11061-68-0/Insulin; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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