| Effect of timing of dialysis commencement on clinical outcomes of patients with planned initiation of peritoneal dialysis in the ideal trial. | |
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MedLine Citation:
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PMID: 23212859 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Since the mid-1990s, early dialysis initiation has dramatically increased in many countries. The Initiating Dialysis Early and Late (IDEAL) study demonstrated that, compared with late initiation, planned early initiation of dialysis was associated with comparable clinical outcomes and increased health care costs. Because residual renal function is a key determinant of outcome and is better preserved with peritoneal dialysis (PD), the present pre-specified subgroup analysis of the IDEAL trial examined the effects of early-compared with late-start dialysis on clinical outcomes in patients whose planned therapy at the time of randomization was PD. ♢ METHODS: Adults with an estimated glomerular filtration rate (eGFR) of 10 - 15 mL/min/1.73 m(2) who planned to be treated with PD were randomly allocated to commence dialysis at an eGFR of 10 - 14 mL/min/1.73 m(2) (early start) or 5 - 7 mL/min/1.73 m(2) (late start). The primary outcome was all-cause mortality. ♢ RESULTS: Of the 828 IDEAL trial participants, 466 (56%) planned to commence PD and were randomized to early start (n = 233) or late start (n = 233). The median times from randomization to dialysis initiation were, respectively, 2.03 months [interquartile range (IQR):1.67 - 2.30 months] and 7.83 months (IQR: 5.83 - 8.83 months). Death occurred in 102 early-start patients and 96 late-start patients [hazard ratio: 1.04; 95% confidence interval (CI): 0.79 - 1.37]. No differences in composite cardiovascular events, composite infectious deaths, or dialysis-associated complications were observed between the groups. Peritonitis rates were 0.73 episodes (95% CI: 0.65 - 0.82 episodes) per patient-year in the early-start group and 0.69 episodes (95% CI: 0.61 - 0.78 episodes) per patient-year in the late-start group (incidence rate ratio: 1.19; 95% CI: 0.86 - 1.65; p = 0.29). The proportion of patients planning to commence PD who actually initiated dialysis with PD was higher in the early-start group (80% vs 70%, p = 0.01). ♢ CONCLUSION: Early initiation of dialysis in patients with stage 5 chronic kidney disease who planned to be treated with PD was associated with clinical outcomes comparable to those seen with late dialysis initiation. Compared with early-start patients, late-start patients who had chosen PD as their planned dialysis modality were less likely to commence on PD. |
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Authors:
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David W Johnson; Muh Geot Wong; Bruce A Cooper; Pauline Branley; Liliana Bulfone; John F Collins; Jonathan C Craig; Margaret B Fraenkel; Anthony Harris; Joan Kesselhut; Jing Jing Li; Grant Luxton; Andrew Pilmore; David J Tiller; David C Harris; Carol A Pollock |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 32 ISSN: 1718-4304 ISO Abbreviation: Perit Dial Int Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: Canada |
Other Details:
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Languages: eng Pagination: 595-604 Citation Subset: IM |
Affiliation:
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Centre for Kidney Disease Research,1 University of Queensland at Princess Alexandra Hospital, Brisbane; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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