Document Detail

Effect of tidal volume on ventilation maldistribution.
MedLine Citation:
PMID:  3786973     Owner:  NLM     Status:  MEDLINE    
To examine the effect of changing tidal volume (VT) on ventilation distribution, we studied multiple breath nitrogen washouts in 4 normal subjects breathing with a VT of 0.6, 1.0 or 1.5 L. We used a recently developed technique of analysis (Crawford et al., 1985) that distinguishes inhomogeneity of gas concentrations due to the interaction of convection and diffusion in the lung periphery (DCDI) from ventilation maldistribution among larger units determined at more proximal branchpoints (CDI). The results indicate that increases in VT reduce the inhomogeneity due to DCDI but increase that due to CDI. In view of the VT dependence of physiological dead space, derived from arterial PCO2, we speculate that the increase in CDI has a dominant effect on gas exchange.
A B Crawford; M Makowska; L A Engel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  66     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-31     Completed Date:  1986-12-31     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  11-25     Citation Subset:  IM; S    
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MeSH Terms
Breath Tests
Lung Volume Measurements*
Nitrogen / analysis
Pulmonary Gas Exchange
Regression Analysis
Respiratory Dead Space
Tidal Volume*
Grant Support
26330//PHS HHS
Reg. No./Substance:

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