Document Detail


Effect of thyroxine therapy on autonomic status in hypothyroid patients.
MedLine Citation:
PMID:  20329368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to evaluate the impact of hypothyroidism on the autonomic regulation of the cardiovascular system by analyzing sympathetic and parasympathetic influences on the heart and the effect of thyroxine replacement. Thirty newly diagnosed female hypothyroid patients with mean age 32.73 +/- 9.98 years were recruited from the Thyroid Clinic, GTB Hospital, Delhi. Various Autonomic function tests to assess Basal heart rate variability, parasympathetic activity (E:I Ratio, 30:15 Ratio, Valsalva Ratio) and sympathetic activity (Postural Challenge test, Sustained handgrip test) were done before and after attainment of euthyroidism. There was significant increase in parasympathetic activity on achieving euthyroid state. The sympathetic activity too significantly improved after L-thyroxine supplementation. Lipid profile parameters significantly decreased after achieving euthyroid state. Our findings are consistent with previous reports that thyroxine therapy appears to restore the efferent vagal activity and alters the relative contribution of systems that maintain resting blood pressure and heart rate.
Authors:
Vijaya Lakshmi; N Vaney; S V Madhu
Related Documents :
25393608 - Quality evaluation of sake treated with a two-stage system of low pressure carbon dioxi...
8861678 - Intravenous instrumentation alters the autonomic state in humans.
14766788 - Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects.
21192248 - Differentiation of arginine vasopressin antagonistic effects by selective v2 versus dua...
2214708 - Rapid flow of passive neutrophils into a 4 microns pipet and measurement of cytoplasmic...
25393608 - Quality evaluation of sake treated with a two-stage system of low pressure carbon dioxi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  53     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    2009 Jul-Sep
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Affiliation:
Department of Physiology, University College of Medical Sciences and GTB Hospital, Delhi - 110 095.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Blood Pressure / drug effects
Electrocardiography
Female
Hand Strength
Heart / innervation*
Heart Rate / drug effects
Hormone Replacement Therapy*
Humans
Hypothyroidism / blood,  drug therapy*,  physiopathology
India
Lipids / blood
Parasympathetic Nervous System / drug effects*,  physiopathology
Posture
Sphygmomanometers
Sympathetic Nervous System / drug effects*,  physiopathology
Thyrotropin / blood
Thyroxine / blood,  therapeutic use*
Treatment Outcome
Triiodothyronine / blood
Valsalva Maneuver
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of daily chlorpromazine administration on behavioural and physiological parameters in the ra...
Next Document:  Comparison of cardiac autonomic activity between pre and post menopausal women using heart rate vari...