| Effect of thyroxine therapy on autonomic status in hypothyroid patients. | |
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MedLine Citation:
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PMID: 20329368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to evaluate the impact of hypothyroidism on the autonomic regulation of the cardiovascular system by analyzing sympathetic and parasympathetic influences on the heart and the effect of thyroxine replacement. Thirty newly diagnosed female hypothyroid patients with mean age 32.73 +/- 9.98 years were recruited from the Thyroid Clinic, GTB Hospital, Delhi. Various Autonomic function tests to assess Basal heart rate variability, parasympathetic activity (E:I Ratio, 30:15 Ratio, Valsalva Ratio) and sympathetic activity (Postural Challenge test, Sustained handgrip test) were done before and after attainment of euthyroidism. There was significant increase in parasympathetic activity on achieving euthyroid state. The sympathetic activity too significantly improved after L-thyroxine supplementation. Lipid profile parameters significantly decreased after achieving euthyroid state. Our findings are consistent with previous reports that thyroxine therapy appears to restore the efferent vagal activity and alters the relative contribution of systems that maintain resting blood pressure and heart rate. |
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Authors:
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Vijaya Lakshmi; N Vaney; S V Madhu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 53 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 2009 Jul-Sep |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 219-26 Citation Subset: IM |
Affiliation:
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Department of Physiology, University College of Medical Sciences and GTB Hospital, Delhi - 110 095. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Pressure / drug effects Electrocardiography Female Hand Strength Heart / innervation* Heart Rate / drug effects Hormone Replacement Therapy* Humans Hypothyroidism / blood, drug therapy*, physiopathology India Lipids / blood Parasympathetic Nervous System / drug effects*, physiopathology Posture Sphygmomanometers Sympathetic Nervous System / drug effects*, physiopathology Thyrotropin / blood Thyroxine / blood, therapeutic use* Treatment Outcome Triiodothyronine / blood Valsalva Maneuver Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
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