Document Detail

Effect of thyroxine therapy on autonomic status in hypothyroid patients.
MedLine Citation:
PMID:  20329368     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to evaluate the impact of hypothyroidism on the autonomic regulation of the cardiovascular system by analyzing sympathetic and parasympathetic influences on the heart and the effect of thyroxine replacement. Thirty newly diagnosed female hypothyroid patients with mean age 32.73 +/- 9.98 years were recruited from the Thyroid Clinic, GTB Hospital, Delhi. Various Autonomic function tests to assess Basal heart rate variability, parasympathetic activity (E:I Ratio, 30:15 Ratio, Valsalva Ratio) and sympathetic activity (Postural Challenge test, Sustained handgrip test) were done before and after attainment of euthyroidism. There was significant increase in parasympathetic activity on achieving euthyroid state. The sympathetic activity too significantly improved after L-thyroxine supplementation. Lipid profile parameters significantly decreased after achieving euthyroid state. Our findings are consistent with previous reports that thyroxine therapy appears to restore the efferent vagal activity and alters the relative contribution of systems that maintain resting blood pressure and heart rate.
Vijaya Lakshmi; N Vaney; S V Madhu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  53     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    2009 Jul-Sep
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Department of Physiology, University College of Medical Sciences and GTB Hospital, Delhi - 110 095.
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MeSH Terms
Biological Markers / blood
Blood Pressure / drug effects
Hand Strength
Heart / innervation*
Heart Rate / drug effects
Hormone Replacement Therapy*
Hypothyroidism / blood,  drug therapy*,  physiopathology
Lipids / blood
Parasympathetic Nervous System / drug effects*,  physiopathology
Sympathetic Nervous System / drug effects*,  physiopathology
Thyrotropin / blood
Thyroxine / blood,  therapeutic use*
Treatment Outcome
Triiodothyronine / blood
Valsalva Maneuver
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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