Document Detail

Effect of thyroid hormones on the activity of hepatic glucose-6-phosphatase in fed and fasted rats.
MedLine Citation:
PMID:  2831125     Owner:  NLM     Status:  MEDLINE    
The action of thyroid hormones on hepatic glucose-6-phosphatase was studied in rats. Fed and 24-h fasted rats received T3 (10 micrograms/day) or T4 (25 micrograms/day) 1 h, 1 or 3 days before sacrificing. In addition a group of fed rats was treated with T4 for 7 and 14 days. The glucose-6-phosphatase activity was measured in the isolated microsomes prepared from the liver. The intactness of the microsomal preparation was checked using 2 mM mannose-6-phosphate as a substrate. In fed rats a single injection of T3 or T4 augmented the activities of the translocase and hydrolase components of glucose-6-phosphatase provided that the rats were killed 24 h after the administration of hormone. This effect was more pronounced in animals treated for 3-14 days. As expected, fasting per se increased the activities of both components of the enzyme. Moreover, in fasted rats treatment with T3 and T4 for 3 days further augmented the activities of the translocase and the hydrolase components of glucose-6-phosphatase. In fed animals T3 and T4 increased the latency of the enzyme whereas in fasted animals thyroid hormones increased the activities of the translocase and hydrolase components in parallel, maintaining the level of latency of the enzyme system. Administration of T3 and T4 increased blood glucose level in fasted rats after one day, while in fed rats a significant hyperglycaemia appeared after 7-14 days of treatment. In conclusion, T3 and T4 increase the activities of the translocase and hydrolase components of hepatic glucose-6-phosphatase in fed and fasted rats.(ABSTRACT TRUNCATED AT 250 WORDS)
A Khan; H Löw; S Efendic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  19     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-04-14     Completed Date:  1988-04-14     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  613-7     Citation Subset:  IM    
Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Blood Glucose / metabolism
Glucose-6-Phosphatase / metabolism*
Insulin / metabolism
Microsomes, Liver / enzymology*
Rats, Inbred Strains
Thyroxine / administration & dosage,  pharmacology*
Triiodothyronine / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; EC

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