Document Detail


Effect of thyroid hormone on growth. Lessons from the syndrome of resistance to thyroid hormone.
MedLine Citation:
PMID:  8879995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid hormone deprivation results in deleterious effects on bone growth. The delayed bone development is mediated by a direct effect of thyroid hormone on bone and an indirect effect of the hormone on GH release and IGF-1 action. Both TR alpha and TR beta are expressed in bone cells. To examine the role of TR beta on bone, we have reviewed the growth abnormalities in the human syndrome of RTH caused by mutations in the TR beta gene. The mutant TR beta reduces the tissue responsiveness to thyroid hormone, producing in some tissues variable degrees of thyroid hormone deprivation. With regard to bone, relative thyroid hormone deficiency caused by the mutant TR beta produces short stature and delayed bone growth but does not attenuate growth to the extent that absolute thyroid hormone deficiency does. These observations indicate that an intact TR beta is required for normal bone development and growth.
Authors:
R E Weiss; S Refetoff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  25     ISSN:  0889-8529     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-08     Completed Date:  1997-01-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  719-30     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Chicago, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Bone and Bones / physiology
Growth / drug effects*,  physiology
Humans
Syndrome
Thyroid Hormone Resistance Syndrome / physiopathology*
Thyroid Hormones / pharmacology*,  physiology
Thyrotropin / pharmacology
Grant Support
ID/Acronym/Agency:
DK-02081/DK/NIDDK NIH HHS; DK-17050/DK/NIDDK NIH HHS; RR-00055/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Thyroid Hormones; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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