Document Detail


Effect of the thromboxane A2 mimetic U 46619 on pial arterioles of rabbits and rats.
MedLine Citation:
PMID:  3603607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our previous experiments have shown that thromboxane A2 is a strong contractor of cerebral arterial smooth muscle strips. The objective of these experiments was to determine if U 46619, a stable thromboxane A2 mimetic, affects the cerebral microcirculation in vivo. Pial arteriole diameter in rabbits and rats was measured with a microscope using the closed cranial window technique. Topical application of 10(-11) to 10(-6) M U 46619 induced dose-dependent arteriole vasoconstriction in both species. In rabbits and rats the maximum vasoconstriction was 9.7 +/- 1.3% (mean +/- SEM) and 14.0 +/- 0.5%, respectively. In rats, 10(-7) and 10(-6) M U 46619 induced intravascular platelet aggregation accompanied by a further decrease in diameter and transient occlusion of the arterioles and venules. U 46619 had no significant effect on rabbit pial arterioles that were predilated by hypercapnia or hypercapnia plus hypoxia. Our data suggest that in animals with a normal vasculature, thromboxane A2 may be a moderate constrictor of cerebral arterioles and that this constrictor effect is prevented by hypercapnia and hypoxia.
Authors:
R L Haberl; M L Heizer; E F Ellis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  18     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1987 Jul-Aug
Date Detail:
Created Date:  1987-08-17     Completed Date:  1987-08-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  796-800     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Animals
Arteries / drug effects*
Arterioles / drug effects*
Dose-Response Relationship, Drug
Drug Combinations
Hypercapnia / physiopathology
Indomethacin / pharmacology
Male
Osmolar Concentration
Pia Mater / blood supply*
Prostaglandin Endoperoxides, Synthetic / pharmacology*
Rabbits
Rats
Thromboxane A2 / pharmacology*
Vasoconstriction
Grant Support
ID/Acronym/Agency:
NS 12587/NS/NINDS NIH HHS; NS 23432/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Prostaglandin Endoperoxides, Synthetic; 53-86-1/Indomethacin; 57576-52-0/Thromboxane A2; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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