Document Detail

Effect of thoracic irradiation on hepatocyte growth factor in rats lung and in bronchoalveolar lavage fluid of patients with thoracic malignancies.
MedLine Citation:
PMID:  9426092     Owner:  NLM     Status:  MEDLINE    
This study aimed to examine the physiological role of hepatocyte growth factor (HGF) after thoracic irradiation. We analysed the changes of HGF protein levels in rat lung following 12 Gy of whole thoracic irradiation. Bronchoalveolar lavage fluid (BALF) was then collected from 11 patients (10 lung cancer and one oesophageal cancer) after completion of radiation therapy. One month after irradiation, the HGF protein level in the lungs of irradiated rats decreased (p<0.05), followed by a remarkable elevation in HGF protein levels 2 (p<0.05) and 3 months (nonsignificant) after irradiation accompanied by the clinical appearance of radiation pneumonitis. Finally, HGF protein levels in the lung returned to their original level 6 months after thoracic irradiation. In humans, HGF protein levels in the BALF in the limited irradiated area were lower than those obtained from unirradiated areas (p<0.05). In conclusion, hepatocyte growth factor production is transiently suppressed in the irradiated area after irradiation.
H Yamazaki; E Takeuchi; J T Tang; S Fukushima; T Inoue; K Shinkawa; Y Watanabe; E Tanaka; T Teshima; S Ozeki; M Koizumi; M Ito; H Nakamura; T Inoue
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  10     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  2539-44     Citation Subset:  IM    
Dept of Radiation Oncology Biomedical Research Center, Osaka University Medical School, Japan.
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MeSH Terms
Bronchoalveolar Lavage Fluid / chemistry*
Enzyme-Linked Immunosorbent Assay
Esophageal Neoplasms / metabolism,  radiotherapy*
Hepatocyte Growth Factor / physiology*,  radiation effects
Lung / metabolism*,  radiation effects
Lung Neoplasms / metabolism,  radiotherapy*
Middle Aged
Radiation Pneumonitis / diagnosis,  metabolism*
Rats, Wistar
Time Factors
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor

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