Document Detail

Effect of thoracic gas compression and bronchodilation on the assessment of expiratory flow limitation during exercise in healthy humans.
MedLine Citation:
PMID:  20138157     Owner:  NLM     Status:  MEDLINE    
Expiratory flow limitation (EFL) during exercise may be overestimated or falsely detected when superimposing tidal breaths within a pre-exercise maximal expiratory flow volume (MEFV) curve due to thoracic gas compression (TGC) and bronchodilation. Accordingly, the purpose of this study was to determine the effects of TGC and bronchodilation on the assessment of EFL in 35 healthy subjects. A pre-exercise forced vital capacity (FVC) maneuver was performed that did not account for TGC (MEFV(pre)). Subjects then performed graded expirations from total lung capacity to residual volume at different efforts to account for TGC (MEFV(pre-TGC)). Post-exercise FVC (MEFV(post)) and post-exercise graded expirations (MEFV(post-TGC)) were performed to account for bronchodilation and TGC. EFL occurred in 29 subjects when using MEFV(pre). The magnitude of EFL in these subjects was 47+/-23% which was significantly higher than MEFV(pre-TGC) (28+/-28%), MEFV(post) (24+/-27%) and MEFV(post-TGC) (19+/-24%) (P<0.00001). Using the traditional MEFV(pre) curve overestimates and falsely detects EFL since it does not account for TGC and bronchodilation.
Jordan A Guenette; Paolo B Dominelli; Sabrina S Reeve; Christopher M Durkin; Neil D Eves; A William Sheel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-04
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  170     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada.
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MeSH Terms
Bicycling / physiology
Bronchi / physiology*
Bronchial Provocation Tests / methods
Exercise / physiology*
Forced Expiratory Flow Rates / physiology*
Forced Expiratory Volume / physiology*
Lung Volume Measurements / methods
Pulmonary Ventilation / physiology*
Respiratory Mechanics / drug effects,  physiology*
Thorax / physiology
Young Adult
Grant Support
//Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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