Document Detail

Effect of thioglycolic acid instillation to stop hair growth on the urethral mucosa after urethroplasty with hairy skin in a rat model.
MedLine Citation:
PMID:  20389156     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to investigate the impact of thioglycolic acid on normal urethral mucosa. METHODS: Twenty-four rats were used. Three control and three study groups were formed each consisting of 4 rats. Controls groups were given 0.9% NaCl and study groups received thioglycolic acid instillation. The groups were allocated according to the time of urethral resection and the number of thioglycolic acid instillations (2, 4 or 8 instillations). The urethras of the rats were resected and examined under a light microscope in control and study groups 1, 2 and 3 on days 15, 30 and 60. RESULTS: There was no difference in the urethral mucosa of rats in the study or control groups, and no differences were found when the study groups were compared to each of the other groups at the microscopic level. CONCLUSION: The application of thioglycolic acid is an easy and inexpensive way of clearing urethral hair and does not cause pathological changes in the normal urethral mucosa.
Melih Sunay; Mümtaz Dadali; Levent Emir; Ayhan Karabulut; Demokan Erol
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Publication Detail:
Type:  Journal Article     Date:  2010-04-13
Journal Detail:
Title:  Urologia internationalis     Volume:  84     ISSN:  1423-0399     ISO Abbreviation:  Urol. Int.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  282-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
1st Clinic of Urology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
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MeSH Terms
Disease Models, Animal
Hair / drug effects*,  growth & development*
Instillation, Drug
Mucous Membrane
Rats, Wistar
Skin Transplantation*
Thioglycolates / administration & dosage*
Urethra / surgery*
Reg. No./Substance:
0/Thioglycolates; 68-11-1/2-mercaptoacetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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