Document Detail

Effect of thiamine pyrophosphate on levels of serum lactate, maximum oxygen consumption and heart rate in athletes performing aerobic activity.
MedLine Citation:
PMID:  19094430     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the effect of thiamine pyrophosphate (TPP) on serum lactate levels, maximum oxygen consumption (Vo(2max)) and heart rate in male athletes performing aerobic activity. A double-blind, randomized, crossover study was performed in which lactate levels, Vo(2max) and heart rates in 27 male athletes were compared at rest and after exercise, following administration of placebo (sodium chloride 0.9%) or TPP (1 mg/kg). At rest, serum lactate levels after placebo or TPP were similar; however, after exercise, the levels were lower in the athletes after taking TPP than after placebo. During exercise, Vo(2max) in athletes on TPP was higher than on placebo. At rest, heart rate after taking placebo or TPP was similar but, after exercise, heart rate was lower after taking TPP than after placebo. It is concluded that TPP caused serum lactate levels and heart rate to be lower than placebo and Vo(2max) to be higher in athletes performing aerobic physical activity.
V M Bautista-Hernández; R López-Ascencio; M Del Toro-Equihua; C Vásquez
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  36     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1220-6     Citation Subset:  IM    
Faculty of Medicine, University of Colima, Colima, Mexico.
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MeSH Terms
Athletic Performance*
Cross-Over Studies
Double-Blind Method
Exercise / physiology
Heart Rate / drug effects*
Lactic Acid / blood*
Oxygen Consumption / drug effects*
Thiamine Pyrophosphate / administration & dosage*
Vitamin B Complex / administration & dosage*
Young Adult
Reg. No./Substance:
12001-76-2/Vitamin B Complex; 154-87-0/Thiamine Pyrophosphate; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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