| Effect of therapeutic dosage of lithium on the heart. | |
MedLine Citation:
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PMID: 7387816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 The cardiac effects of therapeutic levels of lithium were investigated in six healthy male volunteers. Subjects were studied: (1) before lithium ingestion, and (2) when steady-state plasma lithium levels were attained (at least 2 weeks after beginning daily lithium ingestion). 2 A 12-lead electrocardiogram (ECG) and high-speed high-fidelity ECG were used to record electrical activity of the heart. Fractional shortening of the left ventricle using echocardiography, and systolic time intervals (at rest and during exercise), were used as measures of myocardial performance. 3 In this group of healthy volunteers administration of lithium carbonate was associated with a reduction in T wave amplitude in standard electrocardiograms but no statistically significant impairment of myocardial performance. |
Authors:
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P Dumovic; G D Burrows; K Chamberlain; J Vohra; J Fuller; J G Sloman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 9 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-09-28 Completed Date: 1980-09-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 599-604 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Echocardiography Electrocardiography Heart / drug effects* Heart Rate Humans Lithium / pharmacology* Male Physical Exertion Rest Time Factors |
| Chemical | |
Reg. No./Substance:
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7439-93-2/Lithium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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