| Effect of α-thalassemia on exercise-induced oxidative stress in sickle cell trait. | |
| | |
MedLine Citation:
|
PMID: 22409225 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIM: Alpha-thalassemia is known to reduce intra-erythrocyte HbS (sickle hemoglobin) concentration in sickle cell trait (SCT) subjects. Because HbS was shown to increase oxidative stress, the purpose of this study was to assess the effects of the coexistence of α-thalassemia and SCT on oxidative stress markers and nitric oxide (NO) metabolism after an acute physical exercise. METHODS: Forty subjects (age: 23.5±2.21 years), SCT carriers (HbAS) or healthy subjects (HbAA), with (-αT) or without (-NαT) an associated α-thalassemia took part in the study. Plasma markers of oxidative stress [advanced oxidation protein products (AOPP), protein carbonyl, malondialdehyde (MDA), and nitrotyrosine], anti-oxidant defenses and NO metabolism (NOx) were measured at rest (T(rest) ), immediately following an incremental maximal exercise test (T(ex) ) and during recovery (T(1h) , T(2h) , T(24h) ). RESULTS: Malondialdehyde (MDA) expressed as the percentage of changes from baseline was significantly higher in the HbAS-NαT compared with HbAS-αT during recovery (+36.3±14.1% vs. -1.8±13.2% at T(1h) , p=0.02; +36.6±13.4% vs. -11.4±12.5% at T(2h) , p=0.004 and +24.1±12.3% vs. -14.4±11.5% at T(24h) , p=0.02 in HbAS-NαT vs. HbAS-αT). Compared to HbAS-NαT, HbAS-αT had a higher NOx change from baseline at T(ex) (-23.4±20.6% vs. +57.7±19.3%, respectively; p=0.005) and lower Nitrotyrosine change from baseline at T(1h) (+7.2±22.2% vs. +93.5%±29.3%, respectively; p=0.04). CONCLUSION: All these data suggest that the presence of α-thalassemia may blunt the higher level of oxidative stress and the impaired bioavailability of NO observed in the SCT carriers. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society. |
| | |
Authors:
|
Camille Faёs; Cyril Martin; Erica N Chirico; Léonard Féasson; Samuel Oyonno-Enguelle; Hervé Dubouchaud; Alain Francina; Patrice Thiriet; Vincent Pialoux; Laurent Messonnier |
Related Documents
:
|
15233245 - Outcomes of long-term exercise training in dialysis patients: comparison of two trainin... 15552705 - Conservative interventions for carpal tunnel syndrome. 22569195 - Transthoracic detection of coronary flow in left and right coronary descending arteries... 8047535 - Predicting exercise adherence in women: the role of psychological and physiological fac... 8607315 - Effects of ephedrine on oxygen consumption and cardiac output. 15640395 - Leptin gene expression and systemic levels in healthy men: effect of exercise, carbohyd... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-12 |
Journal Detail:
|
Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society. |
Affiliation:
|
Center of Research and Innovation on Sports (CRIS EA647), University Claude Bernard Lyon 1, University of Lyon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of air-abrasion executed with polyacrylic acid-Bioglass 45S5 on the bonding performance of...
Next Document: Indignity, exclusion, pain and hunger: the impact of musculoskeletal impairments in the lives of chi...