Document Detail


Effect of tetrahydrobiopterin and exercise training on endothelium-dependent vasorelaxation in SHR.
MedLine Citation:
PMID:  23011782     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We examined whether the improvement of impaired NO-dependent vasorelaxation by exercise training could be mediated through a BH(4)-dependent mechanism. Male spontaneously hypertensive rats (SHR, n = 20) and Wistar-Kyoto rats (WKY, n = 20) were trained (Tr) for 9 weeks on a treadmill and compared to age-matched sedentary animals (Sed). Endothelium-dependent vasorelaxation (EDV) was assessed with acetylcholine by measuring isometric tension in rings of femoral artery precontracted with 10(-5) M phenylephrine. EDV was impaired in SHR-Sed as compared to WKY-Sed (p = 0.02). Training alone improved EDV in both WKY (p = 0.01) and SHR (p = 0.0001). Moreover, EDV was not different in trained SHR than in trained WKY (p = 0.934). Pretreatment of rings with L-NAME (50 μM) cancelled the difference in ACh-induced relaxation between all groups, suggesting that NO pathway is involved in these differences. The presence of 10(-5) M BH(4) in the organ bath significantly improved EDV for sedentary SHR (p = 0.030) but not WKY group (p = 0.815). Exercise training turned the beneficial effect of BH(4) on SHR to impairment of ACh-induced vasorelaxation in both SHR-Tr (p = 0.01) and WKY-Tr groups (p = 0.04). These results suggest that beneficial effect of exercise training on endothelial function is due partly to a BH(4)-dependent mechanism in established hypertension.
Authors:
François Guerrero; Sanéo Thioub; Christelle Goanvec; Sigrid Theunissen; Annie Feray; Costantino Balestra; Jacques Mansourati
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-26
Journal Detail:
Title:  Journal of physiology and biochemistry     Volume:  -     ISSN:  1877-8755     ISO Abbreviation:  J. Physiol. Biochem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812509     Medline TA:  J Physiol Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
European University of Britany, University of Brest, EA4324 ORPHY, 6 avenue Le Gorgeu, CS 93837, 29238, Brest, France, francois.guerrero@univ-brest.fr.
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