| Effect of tetracycline on pancreas and liver function of adult male albino rats. | |
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MedLine Citation:
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PMID: 17883895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of tetracycline, at two doses of 50 and 200 mg kg(-1) daily, was studied on pancreatic and liver tissue function for 14 and 21 days in adult male albino rats. For pancreatic function the parameters studied were content of amylase and lipase in pancreas, serum amylase and lipase, serum glucose and faecal fat excretion. For liver function, liver specific enzymes in serum, namely alanine amino transaminase, aspartate amino transaminase and lactate dehydrogenase were estimated. In addition, total lipid, antiperoxidative enzymes and lipid peroxidation were measured in pancreas and liver. The content of amylase and lipase in pancreas showed a small but significant decrease in the rats given 50 mg kg(-1) for 21 days and the decrease was much more significant in those receiving the 200 mg kg(-1) dose. In pancreas free radical levels show a significant increase and reduced glutathione shows a substantial decrease at the 50 mg kg(-1) level and a significant change in these parameters was observed at the 200 mg kg(-1) dose. Antioxidant enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase, showed a small but significant decrease in the pancreas of the rats treated with 50 mg kg(-1) tetracycline. A significant decrease in the antioxidant enzymes level was observed at the 200 mg kg(-1) dose. In the liver, free radical levels and reduced glutathione were within the normal range at the 50 mg kg(-1) level and significant changes were observed at 200 mg kg(-1). The antioxidant status was unaffected in liver after treatment with tetracycline at the 50 mg kg(-1) level and a significant decrease was observed at the higher dose. Our results reveal the safe nature of tetracycline with respect to the liver at the lower dose tested, whereas, both the higher and lower doses seem to have detrimental effect on the pancreas as revealed by the rise in free radical levels and decrease in the antioxidant enzyme levels. |
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Authors:
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K K Asha; T V Sankar; P G Viswanathan Nair |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 59 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-21 Completed Date: 2008-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 1241-8 Citation Subset: IM |
Affiliation:
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Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Cochin 682029, India. omanas@sify.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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drug effects,
metabolism Animals Anti-Bacterial Agents / administration & dosage, adverse effects* Blood Glucose / drug effects Catalase / drug effects, metabolism Dose-Response Relationship, Drug Free Radicals / metabolism* Glutathione / drug effects, metabolism Glutathione Peroxidase / drug effects, metabolism Glutathione Reductase / drug effects, metabolism Lipase / drug effects, metabolism Liver / drug effects*, metabolism Liver Function Tests Male Pancreas / drug effects*, metabolism Rats Superoxide Dismutase / drug effects, metabolism Tetracycline / administration & dosage, adverse effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Blood Glucose; 0/Free Radicals; 60-54-8/Tetracycline; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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