| Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. | |
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MedLine Citation:
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PMID: 9870906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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6,9,12,15,18,21-Tetracosahexaenoic acid (24:6n-3) was isolated from a brittle star, Ophiura sarsi Lütken, at >95% purity to evaluate its physiological functions. The effects of 24:6n-3 on the production of leukotriene (LT)-related compounds such as LTB4, LTC4 and 5-hydroxyeicosatetraenoic acid, and the accumulation and release of histamine in an MC/9 mouse mast cell line were studied. We found that 24:6n-3 could inhibit the antigen-stimulated production of LT-related compounds as well as other n-3 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3), which are major n-3 PUFA in fish oils; 24:6n-3 was also shown to reduce the histamine content in MC/9 cells at 25 microM (27% reduction from the control), and the effect was diminished with increase of the fatty acid concentration (up to 100 microM). These two n-3 PUFA, 20:5n-3 and 22:6n-3, also reduced the histamine content (16 and 20% reduction at 25 microM, respectively), whereas arachidonic acid (20:4n-6) increased it (18% increase at 25 microM). Spontaneous- and antigen-induced release of histamine was not influenced with these PUFA (at 25 microM). Ionophore-stimulated release of histamine was suppressed by the PUFA (13, 9, 15, and 11% reduction with 20:4n-6, 20:5n-3, 22:6n-3, and 24:6n-3, respectively). The patterns of the effects of 24:6n-3 on the synthesis of eicosanoids and histamine content were more similar to those of 22:6n-3 than 20:5n-3. From these results, 24:6n-3 can be expected to have anti-inflammatory activity and antiallergic activities similar to those of 22:6n-3. |
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Authors:
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K Ishihara; M Murata; M Kaneniwa; H Saito; K Shinohara; M Maeda-Yamamoto; K Kawasaki; T Ooizumi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 33 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1107-14 Citation Subset: IM |
Affiliation:
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National Research Institute of Fisheries Science, MAFF, Yokohama, Japan. hplc@nrifs.affrc.go.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens / pharmacology Cell Line Docosahexaenoic Acids / isolation & purification, pharmacology* Dose-Response Relationship, Drug Echinodermata / chemistry Eicosanoids / biosynthesis* Fatty Acids, Omega-3 / pharmacology Histamine Release / drug effects* Ionophores / pharmacology Mast Cells / cytology, drug effects*, metabolism Mice |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Eicosanoids; 0/Fatty Acids, Omega-3; 0/Ionophores; 25167-62-8/Docosahexaenoic Acids; 81247-23-6/tetracosahexaenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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