| Effect of testosterone therapy on lumbar spine and hip mineral density in elderly men. | |
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MedLine Citation:
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PMID: 18821290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the present study was to analyse the effect of testosterone therapy on bone mineral density in healthy elderly men who had low levels of total testosterone. DESIGN: Randomized, double-blind, placebo-controlled study. PARTICIPANTS: Forty-eight men over 60 years old with decreased testosterone levels (< or =320 ng/dL) comprised the study. Twenty-five out of 48 received intramuscular injections of testosterone enanthate every three weeks during 12 months; the remaining 23 participants formed the control group. All participants had measurements of bone mineral density (BMD) in both lumbar spine and hip before and at the end of the study as well as testosterone and 17-beta estradiol levels. Results: Testosterone treated group exhibited a significant (p < 0.05) increment (from 1.198 +/- 0.153 to 1.240 +/- 0.141 g/cm(2)) in lumbar BMD in parallel with a significant (p < 0.001) increment (from 301 +/- 32 to 471 +/- 107 ng/dL) in testosterone concentrations, whereas no significant change occurred in femoral neck BMD. CONCLUSIONS: Testosterone therapy elicited a positive effect only in lumbar BMD in elderly men with diminished testosterone serum levels. |
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Authors:
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Lourdes Basurto; Arturo Zarate; Raquel Gomez; Columba Vargas; Renata Saucedo; Rosa Galván |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The aging male : the official journal of the International Society for the Study of the Aging Male Volume: 11 ISSN: 1473-0790 ISO Abbreviation: Aging Male Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-29 Completed Date: 2008-11-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808210 Medline TA: Aging Male Country: United States |
Other Details:
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Languages: eng Pagination: 140-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Endocrine Research Unit and Department of Radiology, National Medical Center, Mexico City, Mexico. lbasurtoa@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Density / drug effects* Double-Blind Method Hip / physiology* Humans Lumbar Vertebrae / physiology* Male Middle Aged Osteoporosis / drug therapy* Testosterone / administration & dosage, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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