Document Detail

Effect of terbutaline, a beta 2-adrenoreceptor agonist, on gastric acid secretion and serum gastrin concentrations in humans.
MedLine Citation:
PMID:  3410234     Owner:  NLM     Status:  MEDLINE    
Because beta-adrenoreceptor agonists inhibit gastrin-stimulated gastric acid secretion in animals, we postulated that the beta 2-adrenoreceptor agonist, terbutaline, would inhibit pentagastrin-stimulated acid secretion in humans. Moreover, we hypothesized that terbutaline might inhibit food-stimulated acid secretion, as gastrin is a major mediator of food-stimulated acid secretion. Subcutaneous terbutaline (0.25 mg) reduced acid secretion during intravenous infusion of a submaximal dose of pentagastrin by 30%-40% (p less than 0.005), even though terbutaline increased serum gastrin levels (p less than 0.05). Furthermore, subcutaneous (0.25 mg) or oral (5 mg) terbutaline, given before a homogenized steak meal was infused into the stomach, lowered mean food-stimulated acid secretion rates, despite enhanced postprandial serum gastrin concentrations. Terbutaline also increased serum gastrin concentrations in patients with Zollinger-Ellison syndrome and in vagotomized individuals. Thus, beta 2-adrenoreceptor agonists enhance gastrin release while at the same time inhibiting gastrin-stimulated acid secretion in humans.
R C Thirlby; C T Richardson; P Chew; M Feldman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  95     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-10-07     Completed Date:  1988-10-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  913-9     Citation Subset:  AIM; IM    
Department of Surgery, Veterans Administration Medical Center, Dallas, Texas.
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MeSH Terms
Gastric Acid / secretion*
Gastrins / blood*
Injections, Subcutaneous
Middle Aged
Propranolol / pharmacology
Terbutaline / administration & dosage,  pharmacology*
Zollinger-Ellison Syndrome / blood*
Grant Support
Reg. No./Substance:
0/Gastrins; 23031-25-6/Terbutaline; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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