| Effect of temperature on myocardial infarction in swine. | |
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MedLine Citation:
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PMID: 8967356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Body core temperature in the normothermic range alters infarct size in rabbits. Moreover, temperature may modulate the protection by adenosine during a coronary artery occlusion. We investigated the effect of core temperature within the normothermic range (35-39 degrees C) on myocardial infarct size produced by a 45-min coronary occlusion in open-chest swine (n = 10), and we determined whether adenosine blockade with 8-phenyltheophylline and adenosine deaminase increased infarct size in the normothermic range (n = 9). After 4 h of reperfusion the area at risk and infarct size were determined with Evans blue dye and triphenyltetrazolium chloride. Infarct size strongly correlated with temperature (r2 = 0.71, P = 0.0001) so that at 35 degrees C no infarction occurred and with each 1 degree C increase in temperature 20% of the area at risk became infarcted. In contrast, neither the low levels of collateral flow (0.03 +/- 0.01 ml.min-1.g-1) nor the rate-pressure product correlated with infarct size. In the normothermic range, adenosine blockade had no effect on infarct size. The data demonstrate that temperature can exert a profound effect on infarct size but fail to demonstrate a protective effect on endogenous adenosine at normothermic temperatures. Our findings emphasize the need for stringent control of core temperature during investigation of interventions aimed at reducing infarct size. |
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Authors:
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D J Duncker; C L Klassen; Y Ishibashi; S H Herrlinger; T J Pavek; R J Bache |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 270 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-12-04 Completed Date: 1996-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1189-99 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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antagonists & inhibitors Adenosine Deaminase / pharmacology Animals Body Temperature* Coronary Circulation Female Heart / physiopathology Hemodynamics Male Myocardial Infarction / pathology*, physiopathology Theophylline / analogs & derivatives, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-21872/HL/NHLBI NIH HHS; HL-32427/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-55-9/Theophylline; 58-61-7/Adenosine; 961-45-5/8-phenyltheophylline; EC 3.5.4.4/Adenosine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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