| Effect of temperature on imipramine hydrochloride permeation: role of lipid bilayer arrangement and chemical composition of rat skin. | |
| | |
MedLine Citation:
|
PMID: 12480294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this investigation was to study the effect of temperature on the permeation of imipramine hydrochloride (IMH) across rat skin from two different vehicles. Differential scanning calorimetry (DSC) was used to characterize the phase transitions of rat epidermis and extracted rat SC lipids, and the transition temperatures were correlated with the permeability of IMH at different temperatures. Permeability of IMH from ethanol and propylene glycol (PG) was determined at five different temperatures and observed that a significant increase in IMH permeability occurred 45 degrees C from both the vehicles. Further, high energies of activation for rat skin permeation suggested that IMH diffuses across intercellular lipid matrix and therefore any change in the packing of SC lipids will have an effect on IMH permeation. Three endotherms T(1), T(2) and T(3) of rat epidermis were observed in DSC thermograms at 44, 53 and 64 degrees C and were assigned as transitions corresponding to orthorhombic to hexagonal, hexagonal to more disordered phase and melting of lipids with high cholesterol content, respectively. The high permeability values of IMH above 45 degrees C were therefore reasoned to be because of orthorhombic to hexagonal phase transition in rat skin from close to that temperature. |
| | |
Authors:
|
Amit Kumar Jain; Ramesh Panchagnula |
Related Documents
:
|
11251204 - Mild postischemic hypothermia is neuroprotective in the immature rat neocortex slice. 2356394 - Sleep deprivation in the rat: xi. the effect of guanethidine-induced sympathetic blocka... 2600044 - Changes in body temperature of rats acclimated to heat with different acclimation sched... 909074 - The effects of temperature acclimation on monoamine metabolism. 2558514 - Glandular kallikrein, renin and angiotensin converting enzyme of diabetic and hypertens... 7397564 - Localization of vasopressin in the rat brain. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: 250 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2002-12-13 Completed Date: 2003-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 287-93 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, Phase-X, SAS Nagar, Mohali 160 062, Punjab, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calorimetry, Differential Scanning Imipramine / administration & dosage* Lipid Bilayers / metabolism* Lipids / analysis* Permeability Rats Rats, Sprague-Dawley Skin / chemistry, metabolism* Temperature |
| Chemical | |
Reg. No./Substance:
|
0/Lipid Bilayers; 0/Lipids; 50-49-7/Imipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison between polyvinylpyrrolidone and silica nanoparticles as carriers for indomethacin in a s...
Next Document: Occupational exposure to organic solvents and long-term nervous system damage detectable by brain im...