Document Detail


Effect of telmisartan on ambulatory blood pressure monitoring, plasma brain natriuretic peptide, and oxidative status of serum albumin in hemodialysis patients.
MedLine Citation:
PMID:  16671338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of telmisartan on ambulatory blood pressure, plasma neurohormonal parameters, and oxidation of serum albumin has not been investigated in hemodialysis (HD) patients. Thirteen hypertensive HD patients were treated with 40 mg telmisartan once daily, and 24-h ambulatory blood pressure monitoring was performed after 0, 4, and 8 weeks of treatment. Plasma renin activity, plasma aldosterone concentration (PAC), brain natriuretic peptide (BNP) level, and serum oxidized albumin level were determined at the same time points. Serum telmisartan concentration was also measured at 4 and 8 weeks. Telmisartan significantly reduced systolic blood pressure and diastolic blood pressure (both awake and sleeping) after 4 weeks, and these pressures showed a further significant decrease after 8 weeks. Plasma levels of aldosterone, BNP, and serum oxidized albumin were markedly decreased after 4 weeks and these lower levels were maintained at 8 weeks. The trough serum telmisartan concentration was not significantly different at 8 weeks compared with 4 weeks. Throughout the treatment period, there were no significant adverse effects. Telmisartan effectively lowers blood pressure and reduces PAC, BNP, and oxidative stress and is safe and well-tolerated by HD patients. A long-term study in a large population is required to determine the influence of telmisartan therapy on cardiovascular mortality and morbidity in HD patients.
Authors:
Hidetaka Shimada; Kenichiro Kitamura; Makoto Anraku; Taku Miyoshi; Masataka Adachi; Do Gia Tuyen; Shiho Wakamatsu; Hiroshi Nonoguchi; Motoko Tanaka; Kimio Tomita
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  28     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-06-05     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  987-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aldosterone / blood
Benzimidazoles / adverse effects,  blood,  pharmacology*
Benzoates / adverse effects,  blood,  pharmacology*
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Female
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Oxidation-Reduction
Renal Dialysis*
Renin / metabolism
Serum Albumin / metabolism*
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Benzoates; 0/Serum Albumin; 114471-18-0/Natriuretic Peptide, Brain; 4964P6T9RB/Aldosterone; EC 3.4.23.15/Renin; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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