| Effect of taurolidine on the normal eyelid and conjunctival flora. | |
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MedLine Citation:
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PMID: 11262606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The effectiveness of the topical taurolidine was evaluated in eradicating or reducing microorganisms in the normal flora of human eyes in a randomized controlled study and analyzed also the irritating effects of taurolidine on the ocular surface. METHODS: One hundred and twenty eyes of 110 patients awaiting cataract surgery were randomly divided into four groups consisting of 30 eyes each. The first group received 0.05% taurolidine, the second received 0.3% gentamicin, the third received vehicle eyedrops and the fourth received saline to the preoperative eye four times daily for two days. Cultures were obtained from the eyelids and conjunctivas of all subjects prior to the therapy and again at the end of 48 hours. Micro-biological identification and colony counts were performed by standard laboratory methods, and the results were compared. The patients were clinically evaluated for symptoms and signs at the end of therapies. RESULTS: Taurolidine and gentamicin produced a significant decrease from the basal bacteriological state: the number of colonies (p < 0.01 for taurolidine, p < 0.01 for gentamicin) was reduced by both agents. Staphylococcus epidermidis was the most common microorganism isolated before therapy, and the number of its colonies was significantly reduced in taurolidine-treated (p < 0.001) and gentamicin-treated (p < 0.01) subjects. There was no significant difference in terms of the irritating effects for all therapies tested (p > 0.05). CONCLUSIONS: Taurolidine solution with its unique properties is an effective antimicrobial agent for reducing the number of bacteria in the flora of the eye. Taurolidine appears to be well tolerated and offers promise as a potential new antimicrobial drug. |
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Authors:
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H Oguz; E Oguz; S Karadede |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Current eye research Volume: 21 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-03-23 Completed Date: 2001-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 851-5 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Harran University School of Medicine, Sanliurfa, Turkey. halitoguz@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Bacterial Agents / administration & dosage, pharmacology Anti-Infective Agents, Local / administration & dosage, pharmacology* Bacteria / drug effects*, isolation & purification Cataract Extraction Colony Count, Microbial Conjunctiva / drug effects*, microbiology Double-Blind Method Drug Evaluation Eye Infections, Bacterial / prevention & control Eyelids / drug effects*, microbiology Female Gentamicins / administration & dosage, pharmacology Humans Male Middle Aged Ophthalmic Solutions Prospective Studies Taurine / administration & dosage, analogs & derivatives*, pharmacology* Thiadiazines / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 0/Gentamicins; 0/Ophthalmic Solutions; 0/Thiadiazines; 107-35-7/Taurine; 19388-87-5/taurolidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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