| Effect of tacrolimus dosing on glucose metabolism in an experimental rat model. | |
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MedLine Citation:
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PMID: 20877268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Post-transplant diabetes mellitus (PTDM) is a serious complication after transplantation. The complex clinical situation makes it difficult to distinct influence of the single factors. To define impact of calcineurin inhibitor therapy on the PTDM after transplantation an experimental study analyzing the impact of different tacrolimus - dosages on the pancreatic beta-cell function was designed. MATERIAL/METHODS: Male Wistar rats received different doses of tacrolimus (0.1, 0.5, 1 and 10 mg/kg day) or tap water for 14 days. Serum glucose, insulin and creatinine levels were measured. Pancreas tissue was fixed in formaldehyde and stained with anti-insulin antibody. Staining intensity was assessed in a semiquantitive, blinded manner. RESULTS: There was no difference in the serum glucose and insulin levels between the tacrolimus treated and the control group. In the 10 mg/kg group the insulin amount in pancreas beta cells was significantly decreased, while the serum creatinine concentration was significantly increased. All other dosages showed no significant influence on function of insulin producing cells. CONCLUSIONS: Tacrolimus in therapeutic dosages has no influence on the pancreas insulin production after 14 days of treatment. In contrast toxic tacrolimus dosages has a decreasing effect on insulin production, but is not associated with hypoinsulinemia. Only high doses of tacrolimus might induce glucose intolerance in transplanted patients. |
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Authors:
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Maciej Malinowski; Johann Pratschke; Johan Lock; Peter Neuhaus; Martin Stockmann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of transplantation : quarterly of the Polish Transplantation Society Volume: 15 ISSN: 1425-9524 ISO Abbreviation: Ann. Transplant. Publication Date: 2010 Jul-Sep |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2011-03-30 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9802544 Medline TA: Ann Transplant Country: Poland |
Other Details:
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Languages: eng Pagination: 60-5 Citation Subset: IM |
Affiliation:
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Department of General, Visceral, and Transplantation Surgery, University Hospital Charité, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / drug effects, metabolism Creatinine / blood Diabetes Mellitus / drug therapy, etiology, physiopathology Disease Models, Animal Dose-Response Relationship, Drug Glucose / metabolism* Glucose Intolerance / complications, drug therapy Hypoglycemic Agents / metabolism, therapeutic use Immunosuppressive Agents / administration & dosage* Insulin / metabolism*, therapeutic use Insulin-Secreting Cells / metabolism Kidney Transplantation / adverse effects, immunology, physiology Male Rats Rats, Wistar Tacrolimus / administration & dosage* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Immunosuppressive Agents; 0/Insulin; 109581-93-3/Tacrolimus; 50-99-7/Glucose; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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