| Effect of tacrolimus derivatives on immunosuppression. | |
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MedLine Citation:
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PMID: 19407973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the effects of the FK506-mPEG on immune cell activity, skin grafting rejection, and Freund's complete adjuvant arthritis were investigated. The proliferation of T cells was inhibited with increase with the FK506 and FK506-mPEG concentrations. FK506 and FK506-mPEG at concentrations between 0.01 nM and 1000 nM had very similar effects on the proliferation of the T cells. On the other hand, in the case of the proliferation of T cells by calcium ionophore A23187 (1 microM), when the FK506-mPEG concentration was increased from 0.01 to 1000 mM, the proliferation was decreased from 90.8 to 40.3%. This was 1.8-fold higher than that of paramethoxyamphetamine (PMA). The inhibitory effect of FK506-mPEG on mast cell proliferation was higher than that of FK506. When B cells were cultured for 7 days in basal medium with no pokeweed mitogen (PWM), the IgG production was 156.2 ng/mL. On the other hand, in the case of the same treatment with 0.25% of PWM, it was 876.4 ng/mL. This is about 5.6-fold higher than with no PWM. These results show that FK506-mPEG may be practically applicable as a prodrug for the immunosuppressant FK506. |
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Authors:
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Dubok Choi; Hoon Cho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-29 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 32 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-01 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 549-57 Citation Subset: IM |
Affiliation:
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Department of Environmental Health, Cho-dang University, Chonnam, 534-800, Korea. hcho@chosun.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation / drug effects Arthritis, Experimental / chemically induced, immunology, prevention & control B-Lymphocytes / drug effects, immunology Cell Line, Tumor Cell Proliferation / drug effects Dose-Response Relationship, Drug Drug Stability Freund's Adjuvant Graft Rejection / etiology, immunology, prevention & control Graft Survival / drug effects Histamine Release / drug effects Humans Immunosuppressive Agents / pharmacology* Male Mast Cells / drug effects, immunology Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred DBA Polyethylene Glycols / pharmacology* Prodrugs / pharmacology* Skin Transplantation / adverse effects T-Lymphocytes / drug effects, immunology Tacrolimus / analogs & derivatives, pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Polyethylene Glycols; 0/Prodrugs; 109581-93-3/Tacrolimus; 9007-81-2/Freund's Adjuvant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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