Document Detail

Effect of tPA on regional lung perfusion in unilobar canine pulmonary thromboembolism.
MedLine Citation:
PMID:  9372664     Owner:  NLM     Status:  MEDLINE    
We investigated effects of tissue-type plasminogen activator (tPA) on regional pulmonary arterial hemodynamics in pulmonary thromboembolism (PTE) in a canine model of unilobar PTE. Ten beagle dogs were divided into two groups-tPA (n = 5) and control group (n = 5). In each dog an artificial blood circuit (ABC) consisting of a silicone tube and a cannulation-type electromagnetic blood flowmeter probe was placed at the left lower pulmonary artery. A unilobar PTE was induced by placing autologous clots into a metallic coil inside the ABC. The CO2 sampling tubes were positioned at the orifice of the left lower bronchus and the trachea, and the end-expiratory CO2 partial pressure (PET(CO2)) was measured. In the tPA group, blood flow at the left lower pulmonary artery (LL-flow) was improved to near baseline within approximately 30 min of receiving tPA, and PET(CO2) at the left lower bronchus (LL-PET(CO2)) increased in direct correlation with LL-flow. The hemodynamic improvement after tPA therapy correlated with the partial pressure of the regional pulmonary expiratory CO2. Moreover, it was suggested that changes in physiologic conditions in PTE were not determined by clot quantity alone.
T Ikeda; S Nakatani; H Takata; M Nosaka; A Yoshikawa; H Tanaka; S Yukawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  156     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-16     Completed Date:  1997-12-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1483-6     Citation Subset:  AIM; IM    
Third Department of Internal Medicine, Wakayama Medical College, Japan.
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MeSH Terms
Blood Pressure
Carbon Dioxide / physiology
Plasminogen Activators / pharmacology*
Pulmonary Artery
Pulmonary Circulation / drug effects*
Pulmonary Embolism / physiopathology*
Pulmonary Gas Exchange
Tissue Plasminogen Activator / pharmacology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

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