| Effect of systemic versus topical nonsteroidal anti-inflammatory drugs on postexercise jaw-muscle soreness: a placebo-controlled study. | |
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MedLine Citation:
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PMID: 9656912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Certain types of jaw-muscle pain may be managed with pharmacologic treatment. This study evaluated the effect of topical and systemic nonsteroidal anti-inflammatory drugs on acute postexercise jaw-muscle soreness. Ten men without temporomandibular disorders performed six 5-minute bouts of submaximal eccentric jaw exercise. The outcome variables were pressure pain thresholds and pain tolerance thresholds at the masseter muscles, and maximum voluntary occlusal force. Surface electromyography from the masseter muscles was used to assess the development of muscle fatigue during the exercise period. Three treatment modalities were tested in a placebo-controlled, double-blind approach: (A) placebo gel and placebo tablets; (B) nonsteroidal anti-inflammatory drug gel (2 g, 5% ibuprofen) and placebo tablets; and (C) placebo gel and nonsteroidal anti-inflammatory drug tablets (400 mg ibuprofen). The subjects used their medication 3 times a day for 3 days in the postexercise period. In the exercise period, the mean power frequency of the electromyography signal, pressure pain threshold, pain tolerance threshold, and maximum voluntary occlusal force decreased significantly (analysis of variance, P < .01). In the postexercise period, the effect of treatment on pressure pain thresholds was significant (F[2,9] = 4.41, P = .02). On day 3, treatment with topical nonsteroidal anti-inflammatory drugs was associated with significantly higher pressure pain thresholds as compared to treatment with systemic nonsteroidal anti-inflammatory drugs (P < .05) and placebo (P < .05). Treatment effects on pain tolerance thresholds and on maximum voluntary occlusal force were nonsignificant. The results demonstrated that repeated eccentric jaw exercise caused muscle fatigue and low levels of postexercise pain and soreness. Topical nonsteroidal anti-inflammatory drugs seem to have some advantages over systemic nonsteroidal anti-inflammatory drugs for management of exercise-induced jaw-muscle pain. |
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Authors:
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P Svensson; L Houe; L Arendt-Nielsen |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of orofacial pain Volume: 11 ISSN: 1064-6655 ISO Abbreviation: J Orofac Pain Publication Date: 1997 |
Date Detail:
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Created Date: 1998-07-16 Completed Date: 1998-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9418507 Medline TA: J Orofac Pain Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 353-62 Citation Subset: D |
Affiliation:
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Center for Sensory-Motor Interaction, Aalborg University, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Administration, Topical Adult Analysis of Variance Anti-Inflammatory Agents, Non-Steroidal / administration & dosage* Bite Force Double-Blind Method Electromyography Exercise Facial Pain / drug therapy*, etiology Humans Ibuprofen / administration & dosage* Male Masseter Muscle / physiopathology* Muscle Contraction Muscle Fatigue Pain Measurement Pain Threshold Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 15687-27-1/Ibuprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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