Document Detail


Effect of systemic and topical application of testosterone propionate on the density of epidermal Langerhans cells in the mouse.
MedLine Citation:
PMID:  2642515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidermal Langerhans cells (LCs) are bone marrow-derived immune cells in the epidermis. Recently, we reported that adenosine triphosphatase (ATPase)-positive LC density in the hind-limb skin of male mice was lower than that of female and that orchiectomy resulted in an increase in LC density, though ovariectomy had no significant effect. To further investigate the control mechanisms of sex differences in LC density, the effect of systemic and topical application of testosterone propionate (TP) on LC density was examined in C57BL/6 mice. Subcutaneous injections of TP 5.8 X 10(-8) mol (20 micrograms)/day/mouse for 14 d resulted in a significant decrease in LC density both in orchiectomized males and normal females, and such an effect was also observed in adrenalectomized mice, suggesting that this effect of TP is not indirectly mediated by glucocorticosteroids. TP was also effective when applied as an ointment (1% or 5%) to the right hind-limb skin of both orchiectomized males and normal females for 14 d; namely, the LC density of the right hind-limb was lower than that of the left. Beta-estradiol and progesterone 5.8 X 10(-8) mol/day/mouse had no significant effect on LC density when systemically applied for 14 d to normal males and females. These results suggest that sex differences in LC density may result from higher concentrations of testosterone or its metabolites in males, and that the function of testosterone may be local.
Authors:
Y Koyama; S Nagao; K Ohashi; H Takahashi; T Marunouchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  92     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-06     Completed Date:  1989-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Affiliation:
Division of Cell Biology, Fujita-Gakuen Health University, Aichi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adrenalectomy
Animals
Cell Count / methods
Female
Fluorescent Antibody Technique
Injections, Subcutaneous
Langerhans Cells / drug effects*,  pathology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Orchiectomy
Sex Factors
Testosterone / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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