Document Detail

Effect of systemic and topical application of testosterone propionate on the density of epidermal Langerhans cells in the mouse.
MedLine Citation:
PMID:  2642515     Owner:  NLM     Status:  MEDLINE    
Epidermal Langerhans cells (LCs) are bone marrow-derived immune cells in the epidermis. Recently, we reported that adenosine triphosphatase (ATPase)-positive LC density in the hind-limb skin of male mice was lower than that of female and that orchiectomy resulted in an increase in LC density, though ovariectomy had no significant effect. To further investigate the control mechanisms of sex differences in LC density, the effect of systemic and topical application of testosterone propionate (TP) on LC density was examined in C57BL/6 mice. Subcutaneous injections of TP 5.8 X 10(-8) mol (20 micrograms)/day/mouse for 14 d resulted in a significant decrease in LC density both in orchiectomized males and normal females, and such an effect was also observed in adrenalectomized mice, suggesting that this effect of TP is not indirectly mediated by glucocorticosteroids. TP was also effective when applied as an ointment (1% or 5%) to the right hind-limb skin of both orchiectomized males and normal females for 14 d; namely, the LC density of the right hind-limb was lower than that of the left. Beta-estradiol and progesterone 5.8 X 10(-8) mol/day/mouse had no significant effect on LC density when systemically applied for 14 d to normal males and females. These results suggest that sex differences in LC density may result from higher concentrations of testosterone or its metabolites in males, and that the function of testosterone may be local.
Y Koyama; S Nagao; K Ohashi; H Takahashi; T Marunouchi
Related Documents :
12668145 - More severe neurologic deficits in sjl/j male than female mice following theiler's viru...
902705 - In vivo synchronization of haemopoietic stem cells with hydroxyurea.
15181195 - Long-term enzymatic and phenotypic correction in the phenylketonuria mouse model by ade...
16925465 - Raloxifen prevents bone loss in castrated male mice.
16887235 - Biosynthesis of malonylated flavonoid glycosides on the basis of malonyltransferase act...
11493445 - Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  92     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-06     Completed Date:  1989-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Division of Cell Biology, Fujita-Gakuen Health University, Aichi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Cutaneous
Cell Count / methods
Fluorescent Antibody Technique
Injections, Subcutaneous
Langerhans Cells / drug effects*,  pathology
Mice, Inbred BALB C
Mice, Inbred C57BL
Sex Factors
Testosterone / administration & dosage,  pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thermolysin treatment: a new method for dermo-epidermal separation.
Next Document:  Monoclonal antibodies to Pneumocystis carinii: identification of specific antigens and characterizat...