Document Detail

Effect of systemic corticosteroids on elective left-sided colorectal resection with colorectal anastomosis.
MedLine Citation:
PMID:  18304503     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The impact of systemic steroid therapy on surgical outcome after elective left-sided colorectal resection with rectal anastomosis is not well known. METHODS: We compared 606 consecutive patients including 53 patients who were on steroids and undergoing surgery between 1995 and 2005. RESULTS: Postoperative mortality and anastomotic leakage rates were equivalent. The postoperative complications rate, especially infections, was higher in steroid-treated patients than in non-steroid-treated patients: 38% (20 of 53 patients) versus 25% (139 of 553 patients), respectively (P = .046). In the steroid group, univariate analysis revealed 3 significant risk factors for postoperative complications: blood transfusion, preoperative anticoagulation, and chronic respiratory failure. In a multivariate analysis, blood transfusion and chronic respiratory failure remained independent factors for postoperative complications. CONCLUSION: Patients on steroids have a higher incidence of postoperative complications after elective left-sided colorectal resection with rectal anastomosis.
Christophe Trésallet; Benoit Royer; Gaëlle Godiris-Petit; Fabrice Menegaux
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  195     ISSN:  1879-1883     ISO Abbreviation:  Am. J. Surg.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-04-01     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  AIM; IM    
Department of General and Digestive Surgery, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie (Paris VI), 75651 Paris Cedex 13, France.
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MeSH Terms
Adrenal Cortex Hormones / administration & dosage*,  adverse effects*
Analysis of Variance
Anastomosis, Surgical
Anticoagulants / administration & dosage
Blood Transfusion
Chronic Disease
Colectomy* / adverse effects,  mortality
Logistic Models
Middle Aged
Postoperative Complications / epidemiology*,  etiology*,  mortality
Proctocolectomy, Restorative / adverse effects,  mortality
Rectum / surgery*
Respiratory Insufficiency
Retrospective Studies
Risk Factors
Surgical Procedures, Elective
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anticoagulants

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