Document Detail

Effect of synthetic porcine neuropeptide Y (NPY) on splanchnic blood flows and exocrine pancreatic secretion in dogs.
MedLine Citation:
PMID:  19160602     Owner:  NLM     Status:  MEDLINE    
This study examined the effect of synthetic porcine neuropeptide Y on the splanchnic blood flows and the exocrine pancreatic secretion in dogs. Graded doses of neuropeptide Y (0.1-5 microg/kg, intravenous) caused dose-dependent reduction of the secretin-stimulated exocrine pancreatic secretion and of the blood flows in the superior mesenteric artery, the portal vein, and the pancreatic tissue. Neuropeptide Y at 5 microg/kg reduced the blood flows to 45.9 +/- 13.3% (superior mesenteric artery), 63.0 +/- 10.5% (portal vein), and 77.9 +/- 4.8% (pancreatic tissue), respectively. This dose also reduced secretin-stimulated pancreatic juice volume and CCK-8 plus secretin-stimulated protein output to 65.2 +/- 9.3 and 63.3 +/- 14.0%, respectively. This study shows a potent vasoconstrictor effect of neuropeptide Y on splanchnic vessels. Neuropeptide Y also inhibited exocrine pancreatic secretion in a significant correlation with the reduction in pancreatic tissue blood flow, which suggests that reduction in the blood flow may be one of the possible mechanisms of the inhibitory action of neuropeptide Y on exocrine secretion.
S Sumi; K Inoue; M Kogire; R Doi; M Yun; H Kaji; R Hosotani; M Fujimura; K Uchida; S Kiyama; K Kitagawa; H Yajima; N Fujii; T Tobe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  36     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  2009-01-22     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1523-8     Citation Subset:  AIM; IM    
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Neuropeptide Y / pharmacology*
Pancreas, Exocrine / blood supply,  drug effects,  secretion*
Regional Blood Flow / drug effects
Splanchnic Circulation / drug effects*
Reg. No./Substance:
0/Neuropeptide Y

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