Document Detail

Effect of synthetic neuromedin-N, a novel neurotensin-like peptide, on exocrine pancreatic secretion and splanchnic blood flow in dogs.
MedLine Citation:
PMID:  3299129     Owner:  NLM     Status:  MEDLINE    
Neuromedin-N, a novel neurotensin-like peptide, has recently been identified from porcine spinal cord by using a bioassay for a stimulatory effect on guinea pig ileum. The amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is quite homologous to the COOH-terminal sequence of neurotensin. In this study, the effect of neuromedin-N on pancreas and splanchnic blood flow was investigated in eight dogs. Intravenous injections of graded doses of synthetic neuromedin-N caused a dose-dependent decrease of systemic arterial pressure and a dose-dependent increase in both portal and superior mesenteric arterial blood flow, which were measured with transit time ultrasonic flow meter. Volume and protein output of the pancreatic juice were also increased significantly by Neuromedin-N. Pancreatic capillary blood flow measured with laser Doppler flowmetry was increased in a dose-related manner. The present study first demonstrated that neuromedin-N retains a potent stimulatory effect on the pancreas and splanchnic circulation, indicating that this peptide is one of the biological active forms of neurotensin-like peptide in mammals. This study also leads to the suggestion that this peptide possesses physiological significance as a novel neuropeptide.
S Sumi; K Inoue; M Kogire; R Doi; K Takaori; H Yajima; T Suzuki; T Tobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropeptides     Volume:  9     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-30     Completed Date:  1987-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Lasers / diagnostic use
Neurotensin / pharmacology*
Pancreas / blood supply*
Pancreatic Juice / drug effects,  secretion*
Peptide Fragments / pharmacology*
Regional Blood Flow / drug effects
Splanchnic Circulation / drug effects*
Reg. No./Substance:
0/Peptide Fragments; 102577-25-3/neuromedin N; 39379-15-2/Neurotensin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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