| Effect of synthetic neuromedin-N, a novel neurotensin-like peptide, on exocrine pancreatic secretion and splanchnic blood flow in dogs. | |
| | |
MedLine Citation:
|
PMID: 3299129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neuromedin-N, a novel neurotensin-like peptide, has recently been identified from porcine spinal cord by using a bioassay for a stimulatory effect on guinea pig ileum. The amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is quite homologous to the COOH-terminal sequence of neurotensin. In this study, the effect of neuromedin-N on pancreas and splanchnic blood flow was investigated in eight dogs. Intravenous injections of graded doses of synthetic neuromedin-N caused a dose-dependent decrease of systemic arterial pressure and a dose-dependent increase in both portal and superior mesenteric arterial blood flow, which were measured with transit time ultrasonic flow meter. Volume and protein output of the pancreatic juice were also increased significantly by Neuromedin-N. Pancreatic capillary blood flow measured with laser Doppler flowmetry was increased in a dose-related manner. The present study first demonstrated that neuromedin-N retains a potent stimulatory effect on the pancreas and splanchnic circulation, indicating that this peptide is one of the biological active forms of neurotensin-like peptide in mammals. This study also leads to the suggestion that this peptide possesses physiological significance as a novel neuropeptide. |
| | |
Authors:
|
S Sumi; K Inoue; M Kogire; R Doi; K Takaori; H Yajima; T Suzuki; T Tobe |
Related Documents
:
|
3101509 - Vital microscopy of islet blood flow: catecholamine effects in normal and ob/ob mice. 22357089 - Use of temporary partial intrailiac balloon occlusion for decreasing blood loss during ... 10919259 - Islet blood flow in multiple low dose streptozotocin-treated wild-type and inducible ni... 830789 - The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune ... 16781679 - Pancreatic vasoconstrictor responses are regulated by neurons in the rostral ventrolate... 7717779 - Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in... 9153619 - Gaze related enhancement of hemispheric blood flow in a stroke patient. 12410679 - Quantitative venous severity scoring using the venous arterial flow index by duplex son... 20861799 - Scintigraphic evaluation of acute lower gastrointestinal hemorrhage: current status and... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuropeptides Volume: 9 ISSN: 0143-4179 ISO Abbreviation: Neuropeptides Publication Date: 1987 Apr |
Date Detail:
|
Created Date: 1987-07-30 Completed Date: 1987-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8103156 Medline TA: Neuropeptides Country: SCOTLAND |
Other Details:
|
Languages: eng Pagination: 247-55 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dogs Dose-Response Relationship, Drug Female Kinetics Lasers / diagnostic use Male Neurotensin / pharmacology* Pancreas / blood supply* Pancreatic Juice / drug effects, secretion* Peptide Fragments / pharmacology* Regional Blood Flow / drug effects Splanchnic Circulation / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Peptide Fragments; 102577-25-3/neuromedin N; 39379-15-2/Neurotensin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quest for a reliable, valid, and sensitive in situ hybridization procedure to detect viral nucleic a...
Next Document: Prevention of deep venous thrombosis in patients with acute spinal cord injuries: use of rotating tr...