| Effect of synthetic human cholecystokinin-33 on pancreatic blood flow in dogs. | |
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MedLine Citation:
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PMID: 2235971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the effect of synthetic human cholecystokinin (CCK-33 and CCK-8) on pancreatic blood flow and protein output in anesthetized dogs. Human CCK-33 and CCK-8 increased pancreatic blood flow and protein output in a dose-related manner. There were no significant differences in increasing pancreatic blood flow between human CCK-33 and CCK-8, and increases in blood flow were closely related to the increase of the pancreatic enzyme secretion. L-364,718 (20 nmol/kg) caused a potent inhibition of CCK-stimulated pancreatic blood flow as well as protein output. The degree of inhibition by L-364,718 was dependent on the amount of CCK infused. This study demonstrates that increasing effect on pancreatic blood flow may be one of the biological actions of CCK mediated via CCK receptor. The CCK-33, one of longer molecular forms of CCK, is an important biological stimulator of pancreatic blood flow as well as of exocrine pancreatic secretion. |
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Authors:
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R Doi; R Hosotani; K Inoue; M Kogire; S Sumi; N Fujii; H Yajima; P L Rayford; T Tobe |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 5 ISSN: 0885-3177 ISO Abbreviation: Pancreas Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-12-19 Completed Date: 1990-12-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 615-20 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Faculty of Medicine, Kyoto University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzodiazepinones / pharmacology Blood Flow Velocity / drug effects Cholecystokinin / antagonists & inhibitors, pharmacology* Devazepide Dogs Female Kinetics Male Pancreas / blood supply*, drug effects, secretion Proteins / secretion Sincalide / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Benzodiazepinones; 0/Proteins; 103420-77-5/Devazepide; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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