Document Detail

Effect of synthetic human cholecystokinin-33 on pancreatic blood flow in dogs.
MedLine Citation:
PMID:  2235971     Owner:  NLM     Status:  MEDLINE    
We have examined the effect of synthetic human cholecystokinin (CCK-33 and CCK-8) on pancreatic blood flow and protein output in anesthetized dogs. Human CCK-33 and CCK-8 increased pancreatic blood flow and protein output in a dose-related manner. There were no significant differences in increasing pancreatic blood flow between human CCK-33 and CCK-8, and increases in blood flow were closely related to the increase of the pancreatic enzyme secretion. L-364,718 (20 nmol/kg) caused a potent inhibition of CCK-stimulated pancreatic blood flow as well as protein output. The degree of inhibition by L-364,718 was dependent on the amount of CCK infused. This study demonstrates that increasing effect on pancreatic blood flow may be one of the biological actions of CCK mediated via CCK receptor. The CCK-33, one of longer molecular forms of CCK, is an important biological stimulator of pancreatic blood flow as well as of exocrine pancreatic secretion.
R Doi; R Hosotani; K Inoue; M Kogire; S Sumi; N Fujii; H Yajima; P L Rayford; T Tobe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pancreas     Volume:  5     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-12-19     Completed Date:  1990-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-20     Citation Subset:  IM    
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Benzodiazepinones / pharmacology
Blood Flow Velocity / drug effects
Cholecystokinin / antagonists & inhibitors,  pharmacology*
Pancreas / blood supply*,  drug effects,  secretion
Proteins / secretion
Sincalide / pharmacology
Reg. No./Substance:
0/Benzodiazepinones; 0/Proteins; 103420-77-5/Devazepide; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

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