Document Detail

Effect of synthetic gizzerosine on growth, mortality, and gizzard erosion in broiler chicks.
MedLine Citation:
PMID:  3237576     Owner:  NLM     Status:  MEDLINE    
Two experiments were conducted to determine the dose-dependent response of synthetic DL-gizzerosine (GIZZ) on the growth, mortality, and gizzard erosion (GE) of male broiler chicks. In a short-term experiment (7 days duration), 4-day-old chicks were fed diets supplemented with 20 levels of GIZZ (from 0 to 18 ppm) in three trials. In a long-term experiment (28 days duration), day-old chicks were fed diets supplemented with eight levels of GIZZ (from 0 to 1 ppm) in two trials. The GE scores, growth and mortality were measured. In the short-term experiment, GE scores of groups fed incremented levels of GIZZ increased rapidly up to 3 ppm of supplemental GIZZ. Weight gain was unaffected until the 1-ppm GIZZ supplementation level was reached, but scores were linearly depressed with increasing increments of dietary GIZZ thereafter. The first mortality occurred at 2 ppm dietary GIZZ, and the mortality rate increased with higher dietary GIZZ levels. In the long-term experiment, the GE scores also increased with increasing increments of supplemental GIZZ. Growth rates of birds fed supplemental GIZZ levels from 0 to .9 ppm were almost the same; growth rate declined at 1.0 ppm GIZZ. Mortality first appeared at .8 ppm supplemental GIZZ. It is suggested that the recommended concentration of GIZZ in practical diets should be less than .4 ppm (L-form).
M Sugahara; T Hattori; T Nakajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  67     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-04-24     Completed Date:  1989-04-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1580-4     Citation Subset:  IM    
Laboratory of Nippon Formula Feed Manufacturing Company, Limited, Ibaraki, Japan.
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MeSH Terms
Body Weight / drug effects*
Chickens / growth & development*
Dose-Response Relationship, Drug
Fish Flour / toxicity*
Fish Products / toxicity*
Gizzard / drug effects*
Imidazoles / administration & dosage,  pharmacology*,  toxicity
Stomach Diseases / chemically induced,  veterinary*
Reg. No./Substance:
0/Imidazoles; 89238-78-8/gizzerosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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